CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110380. doi: 10.1016/j.pnpbp.2021.110380. Epub 2021 Jun 7.
A large number of studies have shown that the pathophysiology of schizophrenia may be involved in sensory gating that appears to be P50 inhibition. However, few studies have investigated the relationship between clinical symptoms, cognitive impairment and sensory gating disorders in patients with first-episode schizophrenia. The purpose of this study was to explore the sex differences in the relationship between clinical symptoms, cognitive impairment and P50 inhibition defects in patients with first-episode schizophrenia, which has not been reported.
130 patients with first-episode schizophrenia (53 males and 77 females) and 189 healthy controls (87 males and 102 females) participated in the study. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the patients' psychopathological symptoms, and the 64-channel electroencephalogram (EEG) system was used to record the P50 inhibition.
Male patients had higher PANSS negative symptom, general psychopathology, cognitive factor and total scores than female patients (all p < 0.01). The S1 amplitude was smaller in male than female patients (all p < 0.05). Multiple regression analysis showed that in male patients, S1 latency was contributor to negative symptoms, while S1 latency, S2 latency, age, and smoking status were contributors to cognitive factor (all p < 0.05). In female patients, no P50 component was found to be an independent contributor to PANSS scores (all p > 0.05).
Our results indicate that there is a sex difference in the relationship between clinical symptoms, cognitive impairment and P50 inhibition defects in Chinese Han patients with first-episode schizophrenia.
大量研究表明精神分裂症的病理生理学可能涉及感觉门控，这似乎是 P50 抑制。然而，很少有研究调查首发精神分裂症患者的临床症状、认知障碍和感觉门控障碍之间的关系。本研究旨在探讨首发精神分裂症患者临床症状、认知障碍与 P50 抑制缺陷之间的性别差异，这尚未有报道。
130 例首发精神分裂症患者（53 名男性和 77 名女性）和 189 名健康对照者（87 名男性和 102 名女性）参与了研究。阳性和阴性综合征量表（PANSS）用于评估患者的精神病理症状，64 通道脑电图（EEG）系统用于记录 P50 抑制。
男性患者的 PANSS 阴性症状、一般精神病性症状、认知因子和总分均高于女性患者（均 p<0.01）。S1 振幅在男性患者中小于女性患者（均 p<0.05）。多元回归分析显示，在男性患者中，S1 潜伏期与阴性症状有关，而 S1 潜伏期、S2 潜伏期、年龄和吸烟状况与认知因子有关（均 p<0.05）。在女性患者中，没有 P50 成分被发现是 PANSS 评分的独立贡献者（均 p>0.05）。
我们的结果表明，中国汉族首发精神分裂症患者的临床症状、认知障碍和 P50 抑制缺陷之间存在性别差异。
