Watts A D, Flint A P, Foxcroft G R, Porter D G
Department of Anatomy, Medical School, Bristol, U.K.
J Reprod Fertil. 1988 Jul;83(2):553-64. doi: 10.1530/jrf.0.0830553.
Recordings of electromyographic and mechanical activities of the uterus of intact and ovariectomized minipigs during the last days of pregnancy, combined with a frequent blood sampling regimen, indicated that the evolution of electrical activity was dependent upon the clearance both of progesterone and relaxin from the plasma. Increases in dihydro-keto-prostaglandin-F-2 alpha (DHKF-2 alpha) occurred only after the initial decline in progesterone, and were positively correlated with increases in electrical activity only after circulating relaxin titres had fallen. These results demonstrate that relaxin provides for the inhibition of the myometrium during the period when progesterone titres decline. The temporal relationship of the decline of progesterone and the rise in DHKF-2 alpha suggests that uterine PGF-2 alpha may not initiate luteolysis in the sow at term.
在妊娠最后几天，对完整和去卵巢小型猪子宫的肌电图和机械活动进行记录，并结合频繁的采血方案，结果表明电活动的演变取决于血浆中孕酮和松弛素的清除。二氢酮前列腺素-F-2α（DHKF-2α）的增加仅在孕酮最初下降之后出现，并且仅在循环松弛素水平下降之后才与电活动的增加呈正相关。这些结果表明，在孕酮水平下降期间，松弛素可抑制子宫肌层。孕酮下降与DHKF-2α升高之间的时间关系表明，足月母猪子宫中的前列腺素F-2α可能不会引发黄体溶解。
