Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China; Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China.
Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China.
Carbohydr Polym. 2021 Sep 1;267:118155. doi: 10.1016/j.carbpol.2021.118155. Epub 2021 May 11.
A series of halloysite nanotube (HNT)-doped chitosan (CS)/oxidized dextran (ODEX) adhesive hydrogels were developed through a Schiff base reaction. The resultant CS/ODEX/HNT hydrogels could not only form in situ on wounds within only 1 s when injected, but could also adapt to wounds of different shapes and depths after injection. We established four rat and rabbit hemorrhage models and demonstrated that the hydrogels are better than the clinically used gelatin sponge for reducing hemostatic time and blood loss, particularly in arterial and deep noncompressible bleeding wounds. Moreover, the natural antibacterial features of CS and ODEX provided the hydrogels with strong bacteria-killing effects. Consequently, they significantly promoted methicillin-resistant Staphylococcus aureus -infected-wound repair compared to commercial gelatin sponge and silver-alginate antibacterial wound dressing. Hence, our multifunctional hydrogels with facile preparation process and utilization procedure could potentially be used as first-aid biomaterials for rapid hemostasis and infected-wound repair in emergency injury events.
通过席夫碱反应开发了一系列埃洛石纳米管（HNT）掺杂壳聚糖（CS）/氧化葡聚糖（ODEX）胶粘剂水凝胶。所得的 CS/ODEX/HNT 水凝胶不仅可以在注射后 1 秒内原位形成于伤口上，而且在注射后还可以适应不同形状和深度的伤口。我们建立了四个大鼠和兔出血模型，并证明水凝胶在减少止血时间和失血量方面优于临床使用的明胶海绵，尤其是在动脉和深部不可压缩性出血伤口中。此外，CS 和 ODEX 的天然抗菌特性为水凝胶提供了强大的杀菌效果。因此，与商业明胶海绵和银藻酸盐抗菌伤口敷料相比，它们显著促进了耐甲氧西林金黄色葡萄球菌感染伤口的修复。因此，我们具有简便制备工艺和使用程序的多功能水凝胶可作为急救生物材料，用于紧急损伤事件中的快速止血和感染伤口修复。
