Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.
College of Life Science, Yantai University, Yantai, Shandong 264000, PR China.
Int J Biol Macromol. 2021 Aug 31;185:229-239. doi: 10.1016/j.ijbiomac.2021.06.046. Epub 2021 Jun 10.
A novel pH-sensitive semi-interpenetrating polymer network (semi-IPN) hydrogel was prepared by using konjac glucomannan (KGM) and poly (γ-glutamic acid) (γ-PGA) with sodium trimetaphosphate (STMP) as the crosslinking agent. The structure of the semi-IPN hydrogels was characterized by FTIR spectra, thermogravimetric analysis (TGA), X-ray diffraction (XRD), rheological measurements, and scanning electron microscopy (SEM). The pH-sensitive effects were investigated by calculating the equilibrium swelling ratio (ESR) in buffer solutions (pH 2, 4, 6, and 8, respectively) at 37 °C. These results showed that the content of cross-linker and γ-PGA has a significant influence on the hydrogels' structure and swelling behavior. In vitro drug release behavior of semi-IPN hydrogels was investigated under simulated gastric and intestinal fluids using model drug Nicotinamide (NTM), and various models were applied to describe the drug release behaviors. The obtained results indicated that our synthesized semi-IPN hydrogel had the potential to be used as a suitable biomaterial carrier for functional components or drug delivery in the intestine.
一种新型的 pH 敏感半互穿聚合物网络（semi-IPN）水凝胶是通过使用魔芋葡甘聚糖（KGM）和聚（γ-谷氨酸）（γ-PGA）与三聚磷酸钠（STMP）作为交联剂制备的。半互穿聚合物网络水凝胶的结构通过傅里叶变换红外光谱（FTIR）、热重分析（TGA）、X 射线衍射（XRD）、流变学测量和扫描电子显微镜（SEM）进行了表征。通过在 37°C 下分别在 pH 2、4、6 和 8 的缓冲溶液中计算平衡溶胀比（ESR）来研究 pH 敏感效应。结果表明，交联剂和 γ-PGA 的含量对水凝胶的结构和溶胀行为有显著影响。通过使用模型药物烟酰胺（NTM）在模拟胃液和肠液下研究了半互穿聚合物网络水凝胶的体外药物释放行为，并应用了各种模型来描述药物释放行为。得到的结果表明，我们合成的半互穿聚合物网络水凝胶有可能作为一种合适的生物材料载体，用于在肠道中传递功能性成分或药物。
