文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

癌相关成纤维细胞衍生的外泌体在缺氧应激下通过外显子circHIF1A经miR-580-5p调节乳腺癌细胞干性。

Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress.

作者信息

Zhan Yanxia, Du Junxian, Min Zhihui, Ma Li, Zhang Wei, Zhu Wei, Liu Yonglei

机构信息

Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.

Research Center, Zhongshan Hospital, Fudan University, Shanghai, China.

出版信息

Cell Death Discov. 2021 Jun 12;7(1):141. doi: 10.1038/s41420-021-00506-z.

DOI:10.1038/s41420-021-00506-z
PMID:34120145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8197761/
Abstract

Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer. The circRNA array analysis was performed to screen differential expressed circRNAs between hypoxic and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their exosomes. Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic CAFs exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression. In a summary, circHIF1A from hypoxic CAFs exosomes played an important role in stem cell properties of breast cancer. CircHIF1A may act as a target molecule of breast cancer therapy.

摘要

缺氧是实体瘤中的常见现象。低氧乳腺癌基质来源的外泌体的作用研究较少。因此，本研究旨在探讨低氧癌相关成纤维细胞（CAFs）来源的外泌体在乳腺癌中的作用。进行环状RNA阵列分析以筛选低氧和常氧CAFs外泌体之间差异表达的环状RNA。筛选出候选环状HIF1A（circ_0032138），并证实其在低氧CAFs来源的外泌体及其外泌体中上调。通过研究包括细胞增殖和干细胞特性在内的细胞功能，证明低氧CAFs外泌体将circHIF1A转移至乳腺癌细胞中，其通过调节CD44表达在癌症干细胞特性中发挥重要作用，海绵化miR-580-5p。总之，低氧CAFs外泌体中的circHIF1A在乳腺癌干细胞特性中发挥重要作用。CircHIF1A可能作为乳腺癌治疗的靶分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/90c96dae3847/41420_2021_506_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/b1ff2151d89b/41420_2021_506_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/3da0f7b34617/41420_2021_506_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/65f753b8a60e/41420_2021_506_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/3f9c43c6b0d5/41420_2021_506_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/61381c84c380/41420_2021_506_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/953d1ad00b2e/41420_2021_506_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/e2468b8e5f3d/41420_2021_506_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/90c96dae3847/41420_2021_506_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/b1ff2151d89b/41420_2021_506_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/3da0f7b34617/41420_2021_506_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/65f753b8a60e/41420_2021_506_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/3f9c43c6b0d5/41420_2021_506_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/61381c84c380/41420_2021_506_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/953d1ad00b2e/41420_2021_506_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/e2468b8e5f3d/41420_2021_506_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2577/8197761/90c96dae3847/41420_2021_506_Fig8_HTML.jpg

相似文献

[1]
Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress.

Cell Death Discov. 2021-6-12

[2]
Exosomal circHIF1A derived from hypoxic-induced carcinoma-associated fibroblasts promotes hepatocellular carcinoma cell malignant phenotypes and immune escape.

Int Immunopharmacol. 2024-9-10

[3]
CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation.

Oncogene. 2021-4

[4]
Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.

J Exp Clin Cancer Res. 2018-10-3

[5]
CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer.

Mol Cancer. 2019-5-7

[6]
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19.

Theranostics. 2018-6-24

[7]
Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer.

Oncogene. 2022-4

[8]
Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway.

Bull Cancer. 2018-4

[9]
Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment.

Exp Cell Res. 2020-4-5

[10]
CD44 expressed on cancer-associated fibroblasts is a functional molecule supporting the stemness and drug resistance of malignant cancer cells in the tumor microenvironment.

Stem Cells. 2014-1

引用本文的文献

[1]
Overcoming cancer treatment resistance: Unraveling the role of cancer-associated fibroblasts.

J Natl Cancer Cent. 2025-3-27

[2]
Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances.

Genes Dis. 2025-3-18

[3]
Deciphering the role of circular RNAs in cancer progression under hypoxic conditions.

Med Oncol. 2025-5-2

[4]
Exosomal circRNAs: key modulators in breast cancer progression.

Cell Death Discov. 2025-4-24

[5]
Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues.

Regen Ther. 2025-3-26

[6]
Pathways and outputs orchestrated in tumor microenvironment cells by hypoxia-induced tumor-derived exosomes in pan-cancer.

Cell Oncol (Dordr). 2025-2-10

[7]
The role of exosomal non-coding RNAs in the breast cancer tumor microenvironment.

Funct Integr Genomics. 2025-2-1

[8]
Exosomes, their sources, and possible uses in cancer therapy in the era of personalized medicine.

J Cancer Res Clin Oncol. 2024-12-26

[9]
Recent Advances of Small Extracellular Vesicles for the Regulation and Function of Cancer-Associated Fibroblasts.

Int J Mol Sci. 2024-11-22

[10]
The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications.

J Mol Med (Berl). 2025-1

本文引用的文献

[1]
Hypoxic Tumor-Derived Exosomal Circ0048117 Facilitates M2 Macrophage Polarization Acting as miR-140 Sponge in Esophageal Squamous Cell Carcinoma.

Onco Targets Ther. 2020-11-18

[2]
Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis.

Theranostics. 2020

[3]
Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2.

Cell Death Dis. 2020-2-24

[4]
The interplay between HIF-1α and noncoding RNAs in cancer.

J Exp Clin Cancer Res. 2020-2-3

[5]
MicroRNA-181d-5p-Containing Exosomes Derived from CAFs Promote EMT by Regulating CDX2/HOXA5 in Breast Cancer.

Mol Ther Nucleic Acids. 2020-3-6

[6]
Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells.

Front Oncol. 2019-5-3

[7]
CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer.

Mol Cancer. 2019-5-7

[8]
Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p.

Cell Mol Biol Lett. 2019-4-2

[9]
Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT.

Mol Cancer. 2019-3-13

[10]
Liquid biopsy in breast cancer: A comprehensive review.

Clin Genet. 2019-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索