Levenson M J, Michaels L, Parisier S C, Juarbe C
Department of Otolaryngology-Head and Neck Surgery, Manhattan Eye, Ear & Throat Hospital, New York, NY 10021.
Laryngoscope. 1988 Sep;98(9):949-55. doi: 10.1288/00005537-198809000-00008.
The clinical findings in 37 children with congenital cholesteatoma of the middle ear, 17 of which have not been previously reported, are presented. Clinical findings and surgical observations are correlated with recent developmental studies. It is hypothesized that congenital cholesteatoma may originate from an epidermoid formation, which has been identified in the anterior superior lateral tympanic cavity adjacent to the anterior annulus during fetal development, and which normally is present early in development, involuting by 33 weeks' gestation. It is proposed that the epidermoid formation may not always involute, and could serve as an embryologic anlage of congenital cholesteatomas.
本文报告了37例中耳先天性胆脂瘤患儿的临床 findings，其中17例此前未曾报道。临床 findings 及手术观察结果与近期的发育研究相关。据推测，先天性胆脂瘤可能起源于一种表皮样结构，该结构在胎儿发育期间于靠近前环的鼓室前上外侧被发现，通常在发育早期出现，至妊娠33周时退化。有人提出，这种表皮样结构可能并非总是退化，可作为先天性胆脂瘤的胚胎学原基。
