Vavassori Andrea, Pennacchioli Elisabetta, Augugliaro Matteo, Durante Stefano, Dicuonzo Samantha, Orsolini Gian Marco, Prestianni Pierpaolo, Cambria Raffaella, Comi Stefania, Mazzarol Giovanni, Cattani Federica, Lazzari Roberta, Orecchia Roberto, Jereczek-Fossa Barbara Alicja
Department of Radiotherapy, IEO European Institute of Oncology IRCCS, Milan, Italy.
Division of Sarcoma and Melanoma, IEO European Institute of Oncology IRCCS, Milan, Italy.
J Contemp Brachytherapy. 2021 Jun;13(3):338-346. doi: 10.5114/jcb.2021.106204. Epub 2021 May 18.
Soft tissue sarcomas of the foot are extremely rare and can therefore be misdiagnosed as benign diseases, and be prematurely removed with an unplanned excision. The standard treatment is a wide local excision with an addition of radiotherapy as an alternative to a radical resection (e.g., below-knee or foot amputation). We report on a patient with primary malignant peripheral nerve sheath tumor in the foot plantar soft tissue, who had no evidence of the disease and no severe late toxicity higher than grade 2, 40 months after receiving amputation of toes and adjuvant interstitial high-dose-rate brachytherapy (HDR-BT). To the best of our knowledge, only a few cases were treated with HDR-BT with this scenario. From our findings, HDR-BT could be a safe and quick treatment option for these types of lesions.
足部软组织肉瘤极为罕见，因此可能被误诊为良性疾病，并在计划外切除的情况下被过早切除。标准治疗方法是广泛局部切除，并辅以放疗，作为根治性切除（如膝下或足部截肢）的替代方案。我们报告了一名足底软组织原发性恶性外周神经鞘瘤患者，在接受截趾及辅助性组织间高剂量率近距离放疗（HDR-BT）40个月后，无疾病证据且无高于2级的严重晚期毒性。据我们所知，在这种情况下，仅有少数病例接受了HDR-BT治疗。根据我们的研究结果，HDR-BT可能是这类病变安全且快速的治疗选择。
