Neugebauer Johannes, Blum Philipp, Keiler Alexander, Süß Markus, Neubauer Markus, Moser Lukas, Dammerer Dietmar
Department of Orthopaedics and Traumatology, Krems University Hospital, 3500 Krems, Austria.
Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Cancers (Basel). 2023 Feb 10;15(4):1133. doi: 10.3390/cancers15041133.
Evidence on the use of brachytherapy in soft-tissue sarcoma (STS) is sparse. Therapy regimens are determined more by local interdisciplinary tumor conferences than by standardized protocols. Patient-specific factors complicate the standardized application of therapy protocols. The individuality of the treatment makes it difficult to compare results.
A comprehensive literature search was conducted, whereby the literature from a period of almost 44 years (1977-2021) was graded and included in this systematic review. For this purpose, PubMed was used as the primary database. Search string included "soft-tissue sarcoma", "brachytherapy", and "extremity." Four independent researchers reviewed the literature. Only full-text articles written in English or German were included.
Of the 175 identified studies, 70 were eligible for analysis based on the inclusion and exclusion criteria. The key points to compare were local complications, recurrence rate and correlation with margins of resection, and the use of brachytherapy regarding tumor grading.
Brachytherapy represents an important subset of radiotherapy techniques used in STSs, whose indications and applications are constantly evolving, and for which a local control rate of 50% to 96% has been reported as monotherapy, depending on risk factors. However, the best benefit is seen in the combination of further resection and brachytherapy, and most authors at many other centers agree with this treatment strategy.
关于近距离放射疗法在软组织肉瘤（STS）中的应用证据稀少。治疗方案更多地由当地多学科肿瘤会议决定，而非标准化方案。患者特异性因素使治疗方案的标准化应用变得复杂。治疗的个体化使得结果难以比较。
进行了全面的文献检索，对近44年（1977 - 2021年）期间的文献进行分级并纳入本系统评价。为此，将PubMed用作主要数据库。检索词包括“软组织肉瘤”“近距离放射疗法”和“肢体”。四名独立研究人员对文献进行了综述。仅纳入用英语或德语撰写的全文文章。
在175项已识别的研究中，70项符合纳入和排除标准，可进行分析。比较的关键点包括局部并发症、复发率及其与切除边缘的相关性，以及近距离放射疗法在肿瘤分级方面的应用。
近距离放射疗法是用于软组织肉瘤的放射治疗技术的一个重要子集，其适应证和应用在不断发展，据报道，作为单一疗法，根据风险因素，局部控制率为50%至96%。然而，进一步切除与近距离放射疗法联合使用时效果最佳，许多其他中心的大多数作者都认同这种治疗策略。
