13,14-脱氢前列环素甲酯对猫肠道血管床的作用

Effects of 13, 14-dehydroprostacyclin methyl ester on the feline intestinal vascular bed.

作者信息

Paustian P W, Chapnick B M, Feigen L P, Hyman A L, Kadowitz P J

出版信息

Prostaglandins. 1977;14(6):1141-52. doi: 10.1016/0090-6980(77)90291-x.

Abstract

The effects of a stable PGI2 analog, 13, 14-dehydro-PGI2 methyl ester and several vasoactive hormones were compared in the feline intestinal vascular bed under conditions of controlled blood flow so that changes in perfusion pressure directly reflect changes in vascular resistance. The PGI2 analog decreased perfusion pressure in a dose-dependent fashion when injected in the range of dose of 0.03-3 microgram and was quite similar to PGE2 whereas isoproterenol was somewhat more potent as a vasodilagor in the feline intestinal vascular bed. The present data show that 13, 14-dehydro-PGI2 methyl ester has potent vasodilator activity in the intestinal vascular bed.

摘要

在控制血流的条件下，比较了一种稳定的前列环素（PGI2）类似物13,14 - 脱氢 - PGI2甲酯与几种血管活性激素对猫肠血管床的作用，以便灌注压力的变化能直接反映血管阻力的变化。当以0.03 - 3微克的剂量范围注射时，PGI2类似物以剂量依赖的方式降低灌注压力，并且与前列腺素E2（PGE2）非常相似，而异丙肾上腺素在猫肠血管床中作为血管扩张剂的作用稍强。目前的数据表明，13,14 - 脱氢 - PGI2甲酯在肠血管床中具有强大的血管舒张活性。