Lippton H L, Paustian P W, Sporl L, Kadowitz P J
Prostaglandins Med. 1980 Nov;5(5):365-73. doi: 10.1016/0161-4630(80)90108-1.
The peripheral vascular effects of PGD2 and PGE2 were investigated in the anesthetized cat. PGD2 and PGE2 caused dose-related decreases in hindquarters and renal perfusion pressure whereas intestinal responses to these substances were divergent. Since regional blood flows were held constant with a pump, changes in perfusion pressure directly reflect changes in hindquarters, renal and intestinal vascular resistance. PGD2 and PGE2 had similar vasodilator activity in the hindquarters vascular bed. In the renal vascular bed, the dilator response to high doses of PGD2 was greater than to PGE2 whereas the low dose of PGE2 produced a greater reduction in renal vascular resistance. In the intestinal vascular bed, bolus injections and infusion of PGE2 decreased vascular resistance whereas PGD2 had biphasic effects possessing an initial vasoconstrictor component. These data demonstrate that PGD2 and PGE2 have significantly vasoactivity in the regional circulation. In addition, the relative vasodilator effects of PGE2 are organ dependent and the effects of PGD2 depend on both organ and dose in the cat.
在麻醉猫身上研究了前列腺素D2（PGD2）和前列腺素E2（PGE2）的外周血管效应。PGD2和PGE2可使后肢和肾灌注压呈剂量依赖性降低，而肠道对这些物质的反应则有所不同。由于通过泵使局部血流量保持恒定，灌注压的变化直接反映后肢、肾和肠道血管阻力的变化。PGD2和PGE2在后肢血管床具有相似的血管舒张活性。在肾血管床，高剂量PGD2的舒张反应大于PGE2，而低剂量PGE2对肾血管阻力的降低作用更大。在肠道血管床，推注和输注PGE2可降低血管阻力，而PGD2具有双相效应，初期有血管收缩成分。这些数据表明，PGD2和PGE2在局部循环中具有显著的血管活性。此外，PGE2的相对血管舒张作用因器官而异，在猫中，PGD2的作用取决于器官和剂量。
