Yang Zhiping, Gu Xiaodong, Han Li-Biao, Wang Jun Joelle
Harbin Institute of Technology Harbin 150080 China.
Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology Shenzhen 518055 China
Chem Sci. 2020 Jun 29;11(28):7451-7455. doi: 10.1039/d0sc01049a.
Despite the importance of -chiral organophosphorus compounds in asymmetric catalysis, transition metal-catalyzed methods for accessing -chiral phosphine derivatives are still limited. Herein, a catalytic enantioselective method for the synthesis of -stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation of alkynes. This process is demonstrated for a wide range of racemic phosphinates and leads to diverse -stereogenic alkenylphosphinates directly.
尽管手性有机磷化合物在不对称催化中具有重要性，但用于制备手性膦衍生物的过渡金属催化方法仍然有限。在此，通过炔烃的不对称氢膦酰化反应，开发了一种催化对映选择性合成手性烯基次膦酸酯的方法。该方法适用于多种外消旋次膦酸酯，并能直接得到多种手性烯基次膦酸酯。
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