D'Amélio Fernanda, Vigerelli Hugo, de Brandão Prieto da Silva Álvaro Rossan, Kerkis Irina
Laboratory of Genetics, Butantan Institute, São Paulo, SP, Brazil.
The Postgraduate Program in Toxinology, Butantan Institute, São Paulo, SP, Brazil.
J Venom Res. 2021 May 28;11:26-33. eCollection 2021.
Belonging to the Viperidae family, are widely distributed in South America, tropical savanna ecoregion (Cerrado) of Argentina, Bolivia, Brazil, and Paraguay with medical importance in Brazil. Accidents caused by this species have a rapid local action with the development of tissue inflammation, causing erythema, pain, and increased clotting time, which can culminate in gangrene or tissue necrosis. venom has a rich composition that remains underexplored, which is of utmost importance, both for elucidating the envenoming process and the vast library of new bioactive molecules kind of venom can offer. This review aims to analyze which components of the venom have already been characterized towards its structure and biological effect and highlight the pharmacological and biotechnological potential of this venom. Although snake venoms have been studied for their toxic effects for generations, innovative studies address their components as tools for discovering new therapeutic targets and new molecules with pharmacological and biotechnological potential.
蝰蛇科的蛇广泛分布于南美洲、阿根廷、玻利维亚、巴西和巴拉圭的热带稀树草原生态区(塞拉多),在巴西具有医学重要性。该物种导致的咬伤具有迅速的局部作用,会引发组织炎症,导致红斑、疼痛和凝血时间延长,最终可能发展为坏疽或组织坏死。其毒液成分丰富,但仍未得到充分研究,这对于阐明中毒过程以及该毒液可能提供的大量新型生物活性分子库至关重要。本综述旨在分析毒液中哪些成分已在结构和生物学效应方面得到表征,并突出这种毒液的药理和生物技术潜力。尽管蛇毒的毒性作用已被研究了几代人,但创新性研究将其成分作为发现新治疗靶点和具有药理及生物技术潜力的新分子的工具。