Czuchnowski Jakub, Prevedel Robert
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Germany.
Photoacoustics. 2021 May 21;23:100276. doi: 10.1016/j.pacs.2021.100276. eCollection 2021 Sep.
All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues .
全光超声检测在光声层析成像方面具有许多独特优势，包括能够对声场进行高分辨率采样以及与多种其他光学模态的兼容性。然而，基于小型化腔的光学方案对光学像差以及制造引起的腔缺陷敏感，这会降低传感器灵敏度并恶化光声图像质量。在此，我们提出一种基于自适应光学的实验方法，该方法能够提高基于法布里 - 珀罗的光声传感器的整体灵敏度。当应用于哺乳动物组织时，我们通过实验观察到光声信号检测以及光声层析成像重建后的整体图像质量有明显改善。
