European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics Unit, Heidelberg, Germany.
Collaboration for Joint PhD Degree beween EMBL and Heidelberg University, Faculty of Biosciences, He, Germany.
J Biomed Opt. 2022 Apr;27(4). doi: 10.1117/1.JBO.27.4.046001.
Highly sensitive detection is crucial for all-optical photoacoustic (PA) imaging. However, free-space optical detectors are prone to optical aberrations, which can degrade the pressure sensitivity and result in deteriorated image quality. While spatial mode-filtering has been proposed to alleviate these problems in Fabry-Pérot-based pressure sensors, their real functional advantage has never been properly investigated.
We rigorously and quantitatively compare the performance of free-space and fiber-coupled detectors for Fabry-Pérot-based pressure sensors.
We develop and characterize a quantitative correlative setup capable of simultaneous PA imaging using a free space and a fiber-coupled detector.
We found that fiber-coupled detectors are superior in terms of both signal level and image quality in realistic all-optical PA tomography settings.
Our study has important practical implications in the field of PA imaging, as for most applications and implementations fiber-coupled detectors are relatively easy to employ since they do not require modifications to the core of the system but only to the peripherally located detector.
高灵敏度检测对于全光学光声（PA）成像是至关重要的。然而，自由空间光学探测器容易受到光学像差的影响，这会降低压力灵敏度，并导致图像质量恶化。虽然已经提出了基于法布里-珀罗的压力传感器中的空间模式滤波来缓解这些问题，但它们的实际功能优势从未得到适当的研究。
我们严格和定量地比较了自由空间和光纤耦合探测器在基于法布里-珀罗的压力传感器中的性能。
我们开发并表征了一种定量相关的设置，该设置能够使用自由空间和光纤耦合探测器同时进行 PA 成像。
我们发现，在现实的全光学 PA 层析成像设置中，光纤耦合探测器在信号水平和图像质量方面都具有优势。
我们的研究在 PA 成像领域具有重要的实际意义，因为对于大多数应用和实现，光纤耦合探测器相对容易使用，因为它们不需要对系统的核心进行修改，而只需要对位于外围的探测器进行修改。
