Lu Fei, Cao Jiating, Su Qinglun, Zhao Qin, Wang Huihai, Guan Weijiang, Zhou Wenjuan
Department of Rehabilitation Medicine, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, China.
Department of Chemistry, Capital Normal University, Beijing, China.
Front Mol Biosci. 2021 May 26;8:660993. doi: 10.3389/fmolb.2021.660993. eCollection 2021.
Traumatic brain injury (TBI) is one of the top three specific neurological disorders, requiring reliable, rapid, and sensitive imaging of brain vessels, tissues, and cells for effective diagnosis and treatment. Although the use of medical imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) for the TBI detection is well established, the exploration of novel TBI imaging techniques is of great interest. In this review, recent advances in fluorescence imaging for the diagnosis and evaluation of TBI are summarized and discussed in three sections: imaging of cerebral vessels, imaging of brain tissues and cells, and imaging of TBI-related biomarkers. Design strategies for probes and labels used in TBI fluorescence imaging are also described in detail to inspire broader applications. Moreover, the multimodal TBI imaging platforms combining MRI and fluorescence imaging are also briefly introduced. It is hoped that this review will promote more studies on TBI fluorescence imaging, and enable its use for clinical diagnosis as early as possible, helping TBI patients get better treatment and rehabilitation.
创伤性脑损伤（TBI）是三大特定神经疾病之一，需要对脑血管、组织和细胞进行可靠、快速且灵敏的成像，以实现有效的诊断和治疗。尽管使用计算机断层扫描（CT）和磁共振成像（MRI）等医学成像技术进行TBI检测已得到广泛应用，但探索新型TBI成像技术仍备受关注。在本综述中，TBI荧光成像在诊断和评估方面的最新进展分为三个部分进行总结和讨论：脑血管成像、脑组织和细胞成像以及TBI相关生物标志物成像。还详细描述了TBI荧光成像中使用的探针和标记的设计策略，以激发更广泛的应用。此外，还简要介绍了结合MRI和荧光成像的多模态TBI成像平台。希望本综述能促进更多关于TBI荧光成像的研究，并使其尽早用于临床诊断，帮助TBI患者获得更好的治疗和康复。
