State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Departments of Diagnostic Radiology, Surgery Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore.
Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202206763. doi: 10.1002/anie.202206763. Epub 2022 Aug 17.
Supramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host-guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli-responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great potential as an important building block of various functional polymers for biomedical applications. In this Minireview, we summarize the most recent examples regarding the design, fabrication, and biomedical applications of CB[n]-based supramolecular polymers (CSPs), which are categorized as noncovalent and covalent CSPs according to the interactions between the CB[n] and polymer backbones. The design principles of CSPs and their unique advantages for biomedical applications, as well as the developmental trends and future perspectives of this cross-disciplinary area are also discussed.
超分子聚合物（SPs）因其独特的性质和功能而受到广泛关注。主体-客体相互作用常常赋予 SPs 可调的物理化学性质、可逆的层次化组织和刺激响应性，从而实现各种生物医学应用。葫芦[n]脲（CB[n]）具有与客体分子形成强但动态相互作用的特点，已显示出作为各种用于生物医学应用的功能聚合物的重要构建块的巨大潜力。在这篇综述中，我们总结了最近关于基于 CB[n]的超分子聚合物（CSPs）的设计、制备和生物医学应用的例子，根据 CB[n]和聚合物主链之间的相互作用，将 CSPs 分为非共价和共价 CSPs。还讨论了 CSPs 的设计原则及其在生物医学应用中的独特优势，以及这个跨学科领域的发展趋势和未来展望。
