Enterprise Technology Center of Guizhou Province, Guizhou University, Guiyang 550025, China.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China.
Molecules. 2023 Apr 19;28(8):3566. doi: 10.3390/molecules28083566.
The cucurbit[n]uril supramolecular hydrogels are driven by weak intermolecular interactions, of which exhibit good stimuli responsiveness and excellent self-healing properties. According to the composition of the gelling factor, supramolecular hydrogels comprise Q[n]-cross-linked small molecules and Q[n]-cross-linked polymers. According to different driving forces, hydrogels are driven by the outer-surface interaction, the host-guest inclusion interaction, and the host-guest exclusion interaction. Host-guest interactions are widely used in the construction of self-healing hydrogels, which can spontaneously recover after being damaged, thereby prolonging their service life. The smart Q[n]s-based supramolecular hydrogel composed is a kind of adjustable and low-toxicity soft material. By designing the structure of the hydrogel or modifying the fluorescent properties, etc., it can be widely used in biomedicine. In this review, we mainly focus on the preparation of Q[n]-based hydrogels and their biomedical applications including cell encapsulation for biocatalysis, biosensors for high sensitivity, 3D printing for potential tissue engineering, drug release for sustained delivery, and interfacial adhesion for self-healing materials. In addition, we also presented the current challenges and prospects in this field.
葫芦脲超分子水凝胶由弱分子间相互作用驱动，具有良好的刺激响应性和出色的自修复性能。根据凝胶因子的组成，超分子水凝胶包括 Q[n]-交联小分子和 Q[n]-交联聚合物。根据不同的驱动力，水凝胶由外表面相互作用、主体-客体包合相互作用和主体-客体排斥相互作用驱动。主体-客体相互作用广泛应用于自修复水凝胶的构建，水凝胶在受到破坏后可以自发恢复，从而延长其使用寿命。由智能 Q[n] 基超分子水凝胶组成的是一种可调、低毒性的软材料。通过设计水凝胶的结构或修饰荧光性质等，可以广泛应用于生物医学领域。在这篇综述中，我们主要关注基于 Q[n]的水凝胶的制备及其在生物医学中的应用，包括用于生物催化的细胞封装、高灵敏度的生物传感器、用于潜在组织工程的 3D 打印、用于持续释放的药物释放以及用于自修复材料的界面粘附。此外，我们还介绍了该领域当前的挑战和前景。
