Courant Thibaut, Gavel Marine, Renard Romain M Q, Gandon Vincent, Joosten Antoine Y P, Lecourt Thomas
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA UMR 6014, 76000 Rouen, France.
Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), CNRS UMR 8182, Université Paris-Saclay, Bâtiment 420, 91405 Orsay Cedex, France.
J Org Chem. 2021 Jul 16;86(14):9280-9288. doi: 10.1021/acs.joc.1c00060. Epub 2021 Jun 14.
An unprecedented hydroalumination of C ═ O bonds catalyzed by zirconocene dichloride is reported herein and applied to the site-selective deprotection of peracetylated functional substrates. A mixed metal hydride, with 1:1 zirconium/aluminum stoichiometry, is also shown to be the reductive species. A catalytic cycle is finally proposed for this transformation with no precedent in the field of zirconium catalysis.
本文报道了一种由二氯锆催化的前所未有的C═O键氢化铝化反应，并将其应用于全乙酰化功能底物的位点选择性脱保护。一种化学计量比为1:1的锆/铝混合金属氢化物也被证明是还原物种。最后提出了该转化的催化循环，这在锆催化领域尚无先例。
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