Bommarito Giulia, Tarun Anjali, Farouj Younes, Preti Maria Giulia, Petracca Maria, Droby Amgad, El Mendili Mohamed Mounir, Inglese Matilde, Van De Ville Dimitri
Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland / Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland / Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland / Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Mult Scler. 2022 Feb;28(2):206-216. doi: 10.1177/13524585211018116. Epub 2021 Jun 14.
Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of the disease at this stage.
To characterize the dynamics of functional networks at rest in patients with PMS, and the relation with clinical disability.
Thirty-two patients with PMS underwent clinical and cognitive assessment. The dynamic properties of functional networks, retrieved from transient brain activity, were obtained from patients and 25 healthy controls (HCs). Sixteen HCs and 19 patients underwent a 1-year follow-up (FU) clinical and imaging assessment. Differences in the dynamic metrics between groups, their longitudinal changes, and the correlation with clinical disability were explored.
PMS patients, compared to HCs, showed a reduced dynamic functional activation of the anterior default mode network (aDMN) and a decrease in its opposite-signed co-activation with the executive control network (ECN), at baseline and FU. Processing speed and visuo-spatial memory negatively correlated to aDMN dynamic activity. The anti-couplings between aDMN and auditory/sensory-motor network, temporal-pole/amygdala, or salience networks were differently associated with separate cognitive domains.
Patients with PMS presented an altered aDMN functional recruitment and anti-correlation with ECN. The aDMN dynamic functional activity and interaction with other networks explained cognitive disability.
在进行性多发性硬化症（PMS）中，脑功能的改变仍相对未被充分研究，尽管在这一阶段其有可能为该疾病的病理生理学提供新的见解。
描述PMS患者静息状态下功能网络的动态变化及其与临床残疾的关系。
32例PMS患者接受了临床和认知评估。从短暂脑活动中获取的功能网络的动态特性，来自患者和25名健康对照（HCs）。16名HCs和19例患者接受了为期1年的随访（FU）临床和影像学评估。探讨了组间动态指标的差异、其纵向变化以及与临床残疾的相关性。
与HCs相比，PMS患者在基线和FU时，前默认模式网络（aDMN）的动态功能激活降低，且与执行控制网络（ECN）的反向共激活减少。处理速度和视觉空间记忆与aDMN动态活动呈负相关。aDMN与听觉/感觉运动网络、颞极/杏仁核或突显网络之间的反耦合与不同的认知领域有不同的关联。
PMS患者表现出aDMN功能募集改变以及与ECN的反相关性。aDMN动态功能活动及其与其他网络的相互作用解释了认知残疾。
