Yang Hongyu, Zhang Chao, Liu Chang, Yu Tao, Zhang Guojun, Chen Nan, Li Kuncheng
Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China.
Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Epilepsy Behav. 2018 Apr;81:41-48. doi: 10.1016/j.yebeh.2018.01.024. Epub 2018 Feb 22.
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance. Functional connectivity (FC) differences of resting state networks (RSNs) were compared among the CI, CNI, and HC groups. Correlation between FC and MoCA scores was also observed. When compared with the HC group, significantly decreased FC between medial visual network (mVN) and left frontoparietal network (lFPN) as well as between visuospatial network (VSN) and the anterior default mode network (aDMN) were revealed in both CI and CNI groups. In addition, significantly decreased FC between lFPN and executive control network (ECN) and increased FC between ECN and sensorimotor-related network (SMN) were found in CNI and CI groups, respectively. When compared with the CNI group, the CI group exhibited significant increased FC between ECN and lFPN as well as between ECN and SMN. Moreover, in the CI group, FC between ECN and lFPN showed negative correlation with attention scores. Our findings suggested that cognitive networks are different from epileptic networks, and the increased FC between RSNs closely related to cognitive function changes may help us to further understand the mechanism of CI in TLE.
本研究的目的是使用功能磁共振成像（fMRI）研究有和无认知障碍（CI）的颞叶癫痫（TLE）患者的脑网络变化，并进一步探索癫痫诱发CI的潜在机制。本研究招募了40例TLE患者和19名健康对照者（HC）。所有参与者均接受蒙特利尔认知评估（MoCA）测试，患者根据MoCA表现分为CI组（n = 21）和认知无损害（CNI）组（n = 19）。比较了CI组、CNI组和HC组静息态网络（RSN）的功能连接（FC）差异。还观察了FC与MoCA评分之间的相关性。与HC组相比，CI组和CNI组内侧视觉网络（mVN）与左侧额顶叶网络（lFPN）之间以及视觉空间网络（VSN）与前默认模式网络（aDMN）之间的FC均显著降低。此外，分别在CNI组和CI组中发现lFPN与执行控制网络（ECN）之间的FC显著降低，以及ECN与感觉运动相关网络（SMN）之间的FC增加。与CNI组相比，CI组在ECN与lFPN之间以及ECN与SMN之间表现出显著增加的FC。此外，在CI组中，ECN与lFPN之间的FC与注意力评分呈负相关。我们的研究结果表明，认知网络与癫痫网络不同，与认知功能变化密切相关的RSN之间增加的FC可能有助于我们进一步了解TLE中CI的机制。
