软骨生物标志物 Coll2-1 和 Coll2-1NO2 与膝关节 OA MRI 特征相关，有助于识别疾病恶化风险的患者。
Cartilage Biomarkers Coll2-1 and Coll2-1NO2 Are Associated with Knee OA MRI Features and Are Helpful in Identifying Patients at Risk of Disease Worsening.
机构信息
ARTIALIS SA, CHU Sart-Tilman, Liège, Belgium.
Department of Rheumatology, CHU Sart Tilman, University of Liège, Liège, Belgium.
出版信息
Cartilage. 2021 Dec;13(1_suppl):1637S-1647S. doi: 10.1177/19476035211021892. Epub 2021 Jun 15.
OBJECTIVE
To assess the cross-sectional association between serum levels of Coll2-1 and Coll2-1NO2, two cartilage degradation biomarkers; the burden of magnetic resonance imaging (MRI) features and clinical outcomes; and to evaluate the predictive value of these biomarkers on progression.
DESIGN
A total of 121 subjects with knee osteoarthritis (OA) were followed during 1 year with pain, function, and MRI assessment (PRODIGE study). Type II collagen-specific biomarker Coll2-1 and its nitrated form Coll2-1NO2 were directly measured in serum using immunoassays at baseline and after 3-, 6-, and 12-month follow-up.
RESULTS
Serum Coll2-1 and Coll2-1NO2 were correlated with several baseline knee features quantified with Whole-Organ Magnetic Resonance Imaging Score (WORMS). Coll2-1 was significantly correlated with periarticular cysts/bursitis (ρ = 0.29, < 0.01), subarticular bone attrition (ρ = 0.25, = 0.01), subarticular cysts (ρ = 0.24, = 0.02), and articular cartilage integrity (ρ = 0.23, = 0.03) WORMS subscores for the whole joint as well as with the medial femorotibial joint sum score (ρ = 0.26, = 0.01) and medial femorotibial joint cartilage (ρ = 0.23, = 0.02). Coll2-1NO2 correlated with WORMS total score (ρ = 0.23, = 0.02), WORMS scores in the patellofemoral (ρ = 0.23, = 0.02) and medial femorotibial compartments (ρ = 0.21, = 0.03), with osteophytes scores (ρ = 0.27, < 0.01), subarticular cysts (ρ = 0.24, = 0.019), and intraarticular loose bodies (ρ = 0.27, = 0.007). Baseline Coll2-1NO2 was higher in subjects with a pain worsening (426.4 pg/mL [278.04-566.95]) as compared to non-progressors (306.84 pg/mL [200.37-427.84]) over 1 year (AUC = 0.655, = 0.015).
CONCLUSION
Serum cartilage biomarkers Coll2-1 and Coll2-1NO2 are associated with several knee OA features quantified with WORMS. Our study also shows that the baseline value of Coll2-1NO2 is positively associated with pain worsening.
目的
评估血清 Coll2-1 和 Coll2-1NO2 这两种软骨降解生物标志物与磁共振成像（MRI）特征和临床结局的横断面相关性；并评估这些生物标志物对进展的预测价值。
设计
121 名膝关节骨关节炎（OA）患者在 PRODIGE 研究中接受了为期 1 年的疼痛、功能和 MRI 评估。在基线和 3、6 和 12 个月随访时，使用免疫测定法直接测量血清中的 II 型胶原特异性生物标志物 Coll2-1 和其硝化形式 Coll2-1NO2。
结果
血清 Coll2-1 和 Coll2-1NO2 与全器官磁共振成像评分（WORMS）量化的几个基线膝关节特征相关。Coll2-1 与周围囊/滑囊炎（ρ=0.29，<0.01）、软骨下骨侵蚀（ρ=0.25，=0.01）、软骨下囊肿（ρ=0.24，=0.02）和关节软骨完整性（ρ=0.23，=0.03）WORMS 总分以及内侧股胫关节总和评分（ρ=0.26，=0.01）和内侧股胫关节软骨（ρ=0.23，=0.02）显著相关。Coll2-1NO2 与 WORMS 总分（ρ=0.23，=0.02）、髌股关节（ρ=0.23，=0.02）和内侧股胫关节（ρ=0.21，=0.03）WORMS 评分、骨赘评分（ρ=0.27，<0.01）、软骨下囊肿（ρ=0.24，=0.019）和关节内游离体（ρ=0.27，=0.007）相关。与 1 年内疼痛加重的患者相比（426.4pg/ml[278.04-566.95]），无进展患者的基线 Coll2-1NO2 水平较高（306.84pg/ml[200.37-427.84]）（AUC=0.655，=0.015）。
结论
血清软骨生物标志物 Coll2-1 和 Coll2-1NO2 与 WORMS 量化的膝关节 OA 多个特征相关。我们的研究还表明，Coll2-1NO2 的基线值与疼痛加重呈正相关。
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