Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México. Sisal, Sisal, YUC, Mexico.
Tecnológico Nacional de México/Instituto Tecnológico de Tizimín, Tizimín, YUC, Mexico.
Bull Environ Contam Toxicol. 2021 Nov;107(5):814-819. doi: 10.1007/s00128-021-03277-6. Epub 2021 Jun 15.
Benzophenone-3 (BP-3) is one of the most used UV filters. The present study aimed to evaluate the toxic effects of BP-3 during embryo stages of zebrafish four hours post-fertilization (4hpf). Embryos were exposed to 0, 1, and 10 µg L of BP-3 for 72 h. We investigated biochemical and molecular biomarkers of neurotoxicity (AChE) and the antioxidant system (gene expression of catalase, CAT, superoxide dismutase, SOD, glutathione peroxidase, GPX, the concentration of total glutathione, GSH, and lipid hydroperoxides, LPO). Results indicated that the acute exposure to BP-3 in zebrafish embryos did not show significant differences in survival, hatching rate, or antioxidant system biomarkers. In contrast, there were significant differences associated with AChE gene expression and activity.
二苯甲酮-3（BP-3）是最常用的紫外线滤光剂之一。本研究旨在评估 BP-3 在斑马鱼胚胎发育的 4 小时后（4hpf）阶段的毒性作用。胚胎在暴露于 0、1 和 10μg/L 的 BP-3 中 72 小时。我们研究了神经毒性的生化和分子生物标志物（乙酰胆碱酯酶）和抗氧化系统（过氧化氢酶、CAT、超氧化物歧化酶、SOD、谷胱甘肽过氧化物酶、GPX、总谷胱甘肽、GSH 和脂质过氧化物、LPO 的基因表达）。结果表明，斑马鱼胚胎的急性 BP-3 暴露在存活率、孵化率或抗氧化系统生物标志物方面没有显著差异。相比之下，AChE 基因表达和活性存在显著差异。
