Klotz Sigrid, Gelpi Ellen
Abteilung für Neuropathologie und Neurochemie, Universitätsklinik für Neurologie, Medizinischer Universitätscampus Wien, Ebene 4J, Währinger Gürtel 18-20, 1090, Wien, Österreich.
Österreichisches Referenzzentrum zur Erfassung und Dokumentation menschlicher Prionen-Erkrankungen (ÖRPE), Wien, Österreich.
Wien Med Wochenschr. 2021 Sep;171(11-12):257-273. doi: 10.1007/s10354-021-00848-4. Epub 2021 Jun 15.
Dementia is the clinical consequence of various neurological disorders with a multitude of etiologies. Precise knowledge of the underlying pathologies is essential for an accurate treatment of patients and for the development of suitable disease biomarkers. A definite diagnosis of many of the disorders, particularly for neurodegenerative ones, can only be made after a thorough postmortem neuropathological examination. This highlights the importance of performing a brain autopsy and the relevance of a close interaction between clinicians, neuroimaging disciplines and neuropathologists as well as with basic researchers. This article aims to give a brief overview on the neuropathology of dementia focusing on neurodegenerative diseases, to further facilitate interdisciplinary collaboration.
痴呆是多种病因导致的各种神经系统疾病的临床后果。准确了解潜在病理对于准确治疗患者以及开发合适的疾病生物标志物至关重要。许多疾病,尤其是神经退行性疾病,只有在进行全面的死后神经病理学检查后才能做出明确诊断。这凸显了进行脑尸检的重要性,以及临床医生、神经影像学学科、神经病理学家以及基础研究人员之间密切互动的相关性。本文旨在简要概述以神经退行性疾病为重点的痴呆神经病理学,以进一步促进跨学科合作。