Faculty Member at King Saud Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia; School of Biomedical Science, University of Alabama at Birmingham, Birmingham, AL, United States; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Faculty Member at King Saud Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia; Department of Rehabilitation Science, School of Health Profession, University of Alabama at Birmingham, Birmingham, AL, United States; King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
J Infect Public Health. 2021 Jul;14(7):954-959. doi: 10.1016/j.jiph.2021.05.007. Epub 2021 May 26.
Coronavirus disease 2019 (COVID-19) often results in pneumonia and can lead to acute respiratory distress syndrome (ARDS). ARDS is one of the most significant causes of death in patients with COVID-19. The development of a "cytokine storm" in patients with COVID-19 causes progression to ARDS. In this scoping review, we investigated the effect of pro-inflammatory cytokines in inducing moderate and severe ARDS outcomes. A comprehensive search was performed using PubMed and Google Scholar to implement a broad query that captured all the relevant studies published between December 2019 and September 2020.We identified seven studies that evaluated the immune response in COVID-19 patients with ARDS. The white blood cell counts (WBCs), CRP, and IL-6 were higher in the moderately presenting ARDS patients, critically ill patients, and those with more severe ARDS. This study may contribute to better patient management and outcomes if tailored immune marker interventions are implemented in the near future.
新型冠状病毒病 2019（COVID-19）常导致肺炎，并可导致急性呼吸窘迫综合征（ARDS）。ARDS 是 COVID-19 患者死亡的主要原因之一。COVID-19 患者发生“细胞因子风暴”会导致 ARDS 进展。在本范围综述中，我们研究了促炎细胞因子在诱导中度和重度 ARDS 结局中的作用。使用 PubMed 和 Google Scholar 进行了全面检索，实施了广泛的查询，以捕获 2019 年 12 月至 2020 年 9 月期间发表的所有相关研究。我们确定了七项评估 ARDS 患者 COVID-19 免疫反应的研究。白细胞计数（WBC）、C 反应蛋白（CRP）和白细胞介素 6（IL-6）在表现为中度 ARDS 的患者、危重症患者和 ARDS 更严重的患者中更高。如果在不久的将来实施针对免疫标志物的干预措施，这项研究可能有助于更好地管理患者并改善结局。
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