Watt B
Scott Med J. 1977 Dec;22(5):389-91. doi: 10.1177/00369330770220S108.
Anaerobic organisms are being increasingly recognised as important causes of serious infection in man. Sampling procedures, transport of specimens and laboratory techniques need to be constantly monitored and improved if the causative organisms are to be consistently recovered from clinical specimens. Once the organisms have been isolated, their susceptibility to antibiotics should be determined so that the clinician can base his antibiotic therapy on reliable laboratory results. There are many variables in the sensitivity testing of anaerobes--these may account for the difficulty reported by some workers in obtaining consistently reliable results with some antibiotics, including erythromycin. These problems can be largely overcome if a standardised procedure is adopted. It is clear from the published data that erythromycin has considerable in vitro activity against many strains of anaerobic bacteria, both sporing and non-sporing. There is a broad spectrum of activity with some strains being very sensitive and a few strains being resistant. M.I.C. values range from 0.04 microgram./ml. to 20 microgram./ml. or more. Further studies are now needed to assess the role of erythromycin in the treatment of anaerobic infections in vivo.
厌氧生物越来越被认为是人类严重感染的重要病因。如果要从临床标本中持续分离出致病生物，采样程序、标本运输和实验室技术需要不断监测和改进。一旦分离出这些生物，就应确定它们对抗生素的敏感性，以便临床医生能够根据可靠的实验室结果进行抗生素治疗。厌氧菌敏感性测试中有许多变量——这些可能是一些研究人员在使用某些抗生素（包括红霉素）获得一致可靠结果时遇到困难的原因。如果采用标准化程序，这些问题在很大程度上是可以克服的。从已发表的数据中可以清楚地看出，红霉素对许多厌氧细菌菌株（包括产芽孢和不产芽孢的菌株）具有相当大的体外活性。其活性谱很广，一些菌株非常敏感，少数菌株耐药。最低抑菌浓度值范围为0.04微克/毫升至20微克/毫升或更高。现在需要进一步研究来评估红霉素在体内治疗厌氧感染中的作用。
