Chow A W, Patten V, Guze L B
J Infect Dis. 1975 Feb;131(2):182-5. doi: 10.1093/infdis/131.2.182.
Susceptibility of 358 clinical isolates of obligate anaerobes to metronidazole was determined by an agar-dilution technique. Only 66% of all isolates were inhibited by 6.25 mug/ml, whereas 30% required larger than or equal to 50 mug/ml. Considerable variation in susceptibility was observed among different genera and species of bacteria. Fusobacterium was most senstitive, followed by Clostridium, Bacteroides and Peptococcus, Peptostreptococcus, Veillonella and Acidaminococcus, and non-spore-forming gram-positive bacilli. Bacteroides fragilis was more sensitive than other species of Bacteroides. Similarly, Clostridium perfringens was more susceptible than other species of Clostriduim. While metronidazole appears to be a promising antimicrobial agent for infections caused by Fusobacterium, Clostrididium, and B.fragilis, therapy for infections with other anaerobic bacteria should be guided by in vitro tests of sensitiivity.
采用琼脂稀释法测定了358株专性厌氧菌临床分离株对甲硝唑的敏感性。所有分离株中只有66%被6.25μg/ml抑制，而30%需要大于或等于50μg/ml。在不同属和种的细菌之间观察到敏感性有相当大的差异。梭杆菌最敏感，其次是梭菌、拟杆菌、消化球菌、消化链球菌、韦荣球菌和氨基酸球菌，以及无芽孢革兰氏阳性杆菌。脆弱拟杆菌比其他拟杆菌属物种更敏感。同样，产气荚膜梭菌比其他梭菌属物种更敏感。虽然甲硝唑似乎是治疗由梭杆菌、梭菌和脆弱拟杆菌引起的感染的一种有前景的抗菌药物，但对于其他厌氧菌感染的治疗应以体外敏感性试验为指导。
