Natelson B H, Ottenweller J E, Cook J A, Pitman D, McCarty R, Tapp W N
Primate Neuro-Behavioral Unit, VA Medical Center, East Orange, NJ 07019.
Physiol Behav. 1988;43(1):41-6. doi: 10.1016/0031-9384(88)90096-0.
Although it is known that the number of presentations of a stressor can influence the adrenocortical stress response, relatively little information exists on how stressor intensity affects this process. To evaluate this, we repeatedly presented rats with stressors of 3 different intensities and sampled blood for corticosterone. The first major finding was that the rat's initial adrenocortical responsiveness regardless of the stressor employed was a critical variable. Rats that showed a small corticosterone response showed no evidence of habituation or of differences due to stressor intensity. Rats that showed an initial robust response all showed partial habituation of their corticosterone response over time but the patterns varied with stressor intensity. Handled and prone restrained rats showed the same pattern but rats subjected to the more intense stressor of supine restraint showed delay in habituation and tonically elevated responses. These data indicate that individual differences in reactivity to stressors as well as stressor intensity can influence the pattern of the stress response over the course of repeated administration of the stressor.
尽管已知应激源的呈现次数会影响肾上腺皮质应激反应，但关于应激源强度如何影响这一过程的信息相对较少。为了评估这一点，我们反复给大鼠施加3种不同强度的应激源，并采集血液检测皮质酮。第一个主要发现是，无论采用何种应激源，大鼠最初的肾上腺皮质反应性都是一个关键变量。皮质酮反应较小的大鼠没有表现出习惯化的迹象，也没有因应激源强度而产生差异。最初表现出强烈反应的大鼠随着时间的推移，其皮质酮反应都出现了部分习惯化，但模式因应激源强度而异。经处理和俯卧约束的大鼠表现出相同的模式，但接受更强烈的仰卧约束应激源的大鼠表现出习惯化延迟和反应持续升高。这些数据表明，对应激源反应性的个体差异以及应激源强度，在反复施加应激源的过程中会影响应激反应的模式。
