Armario A, Marti J, Gil M
Departamento de Biología Celular y Fisiología, Facultad de Ciencias, Universidad Autónoma de Barcelona, Spain.
Psychoneuroendocrinology. 1990;15(5-6):341-7. doi: 10.1016/0306-4530(90)90059-i.
The reliability of serum glucose concentrations as an index of habituation to chronic stress was evaluated in adult male rats. The glucose response to immobilization was attenuated by six days of previous chronic exposure to the same stressor, the degree of reduction being related to the duration (15 min, 1 hr or 4 hr) of the daily exposure to immobilization. In another experiment, three groups of rats were exposed to one of three stressors (handling plus change of room, restraint in tubes, or immobilization by wood boards), 1 hr daily for 27 days. On day 28, when faced with the same acute stressor to which they were chronically exposed, the rats showed a consistent reduction in glucose response, regardless of the type of stressor used. In addition, in stress-naive rats serum glucose levels were related to the intensity of the stressor as assessed by three independent measures (food intake, body weight changes, and adrenal weight after chronic exposure to the stressor). These data indicate that, under appropriate conditions, glucose levels can be a good index of both the intensity of acute stress experienced by the rats and their habituation to repeated stress.
在成年雄性大鼠中评估了血清葡萄糖浓度作为慢性应激适应指标的可靠性。先前连续六天慢性暴露于相同应激源会使对固定应激的葡萄糖反应减弱，降低程度与每日固定应激暴露的持续时间（15分钟、1小时或4小时）相关。在另一项实验中，三组大鼠分别暴露于三种应激源（抚摸加更换饲养室、限制在管中或用木板固定）之一，每天1小时，持续27天。在第28天，当面对它们长期暴露的相同急性应激源时，无论使用何种应激源类型，大鼠的葡萄糖反应均持续降低。此外，在未经历过应激的大鼠中，血清葡萄糖水平与应激源强度相关，该强度通过三项独立指标评估（食物摄入量、体重变化以及长期暴露于应激源后的肾上腺重量）。这些数据表明，在适当条件下，葡萄糖水平可以很好地反映大鼠所经历的急性应激强度及其对重复应激的适应情况。
