连续坐姿时间减少可增加心血管危险因素患者的心率变异性。
Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors.
机构信息
Nagoya University Graduate School of Medicine, Higashi-ku, Nagoya, Japan.
Chutoen General Medical Center, Kakegawa, Shizuoka, Japan.
出版信息
PLoS One. 2021 Jun 16;16(6):e0253399. doi: 10.1371/journal.pone.0253399. eCollection 2021.
AIM
The purpose of the present study was to elucidate the relationship between high-frequency heart rate variability (HF HRV) and continuous daytime sitting time in patients with cardiovascular risk factors such as mild hypertension and/or stable angina pectoris.
BACKGROUND
Decreased HF HRV precedes the progression and worsening of cardiovascular diseases. Continuous sitting behavior is a major risk factor for developing metabolic syndrome and is associated with cardiovascular disease, diabetes mellitus, renal failure, sarcopenia and osteoporosis. Risk factors for cardiovascular disease can be affected by continuous daytime sitting behaviors.
DESIGN
The present study design was a post-hoc comparison.
METHODS
Patients treated at two different primary care clinics from 2014 to 2018 were enrolled in this study (n = 53). We assessed HF HRV and continuous sitting time using 24-hour Holter electrocardiography and an activity meter at baseline and 6 months. HF HRV was calculated during sleep.
RESULTS
Sitting time had decreased in 22 patients (decreased group) and increased in 31 patients (increased group) after 6 months. The mean patient ages were 73.1 and 72.0 years in the decreased and increased sitting time groups, respectively (p = 0.503). HF HRV during sleep had increased after 6 months in the decreased sitting time group. Compared with the increased group, the decreased group showed significantly higher HF HRV during sleep after 6 months by two-way repeated-measures ANOVA after adjustment for age, sex and change in activity (p = 0.045).
CONCLUSION
These results suggest that a decrease in sitting time might induce parasympathetic activity during sleep. Therefore, reducing continuous sitting time during the day might contribute, in part, to improving the prognosis of patients with cardiovascular risk factors not only by avoiding muscle loss but also by providing positive influences on parasympathetic tone during sleep.
目的
本研究旨在阐明高频心率变异性（HF HRV）与轻度高血压和/或稳定型心绞痛等心血管危险因素患者连续白天久坐时间之间的关系。
背景
HF HRV 降低先于心血管疾病的进展和恶化。连续久坐行为是代谢综合征发展的主要危险因素，与心血管疾病、糖尿病、肾衰竭、肌肉减少症和骨质疏松症有关。心血管疾病的危险因素可能受到连续白天久坐行为的影响。
设计
本研究设计为事后比较。
方法
本研究纳入了 2014 年至 2018 年在两家不同初级保健诊所接受治疗的患者（n=53）。我们在基线和 6 个月时使用 24 小时动态心电图和活动计评估了 HF HRV 和连续久坐时间。HF HRV 在睡眠期间进行计算。
结果
6 个月后，22 名患者（减少组）的久坐时间减少，31 名患者（增加组）的久坐时间增加。减少和增加久坐时间组的患者平均年龄分别为 73.1 岁和 72.0 岁（p=0.503）。减少久坐时间组的睡眠期间 HF HRV 在 6 个月后增加。与增加组相比，经过年龄、性别和活动变化调整后，双向重复测量方差分析显示，减少久坐时间组在 6 个月后睡眠期间的 HF HRV 显著更高（p=0.045）。
结论
这些结果表明，减少久坐时间可能会在睡眠期间诱导副交感神经活动。因此，减少白天连续久坐时间不仅可以避免肌肉流失，而且可以对睡眠期间的副交感神经张力产生积极影响，从而可能有助于改善心血管危险因素患者的预后。
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