Université de Paris, CNRS, Institut Jacques Monod, Paris, France.
Université de Paris, CNRS, Institut Jacques Monod, Paris, France.
Curr Opin Cell Biol. 2021 Oct;72:54-62. doi: 10.1016/j.ceb.2021.04.006. Epub 2021 Jun 13.
Collective cell migration is crucial to maintain epithelium integrity during developmental and repair processes. It requires a tight regulation of mechanical coordination between neighboring cells. This coordination embraces different features including mechanical self-propulsion of individual cells within cellular colonies and large-scale force transmission through cell-cell junctions. This review discusses how the plasticity of biomechanical interactions at cell-cell contacts could help cellular systems to perform coordinated motions and adapt to the properties of the external environment.
细胞集体迁移对于在发育和修复过程中维持上皮组织的完整性至关重要。它需要严格调节相邻细胞之间的力学协调性。这种协调性包括细胞群体中单个细胞的力学自主推进以及通过细胞-细胞连接的大规模力传递等不同特征。本文讨论了细胞-细胞接触处生物力学相互作用的可变性如何帮助细胞系统进行协调运动，并适应外部环境的特性。
