口腔扁平苔藓中平均血小板体积升高和红型血尿素氮水平升高：一项观察性研究。

Elevated mean platelet volume in oral lichen planus and increased blood urea nitrogen level in its red-form: an observational study.

机构信息

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.

College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.

出版信息

BMC Oral Health. 2021 Jun 16;21(1):310. doi: 10.1186/s12903-021-01659-0.

DOI:10.1186/s12903-021-01659-0

PMID:34134686

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8207752/

Abstract

BACKGROUND

This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients.

METHODS

Eighty pathologically confirmed OLP patients and 51 healthy controls were enrolled. Data on full blood count and biochemical tests were obtained from the electronic medical record system of the hospital.

RESULTS

MPV was elevated in OLP patients compared to controls (10.68 ± 0.97 fL versus 10.33 ± 0.89 fL, P = 0.042) while platelet count showed no difference between them. Red-form OLP group had increased blood urea nitrogen (BUN, 5.24 ± 1.15 mmol/L versus 4.69 ± 0.98 mmol/L, P = 0.036) than white-form OLP group. By contrast, there were no differences between those two groups in the other variables including MPV, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine. In terms of C-reactive protein (CRP), 92.5% of the OLP patients had a value of less than 3.48 mg/L. Besides, 75% of the OLP patients were overweight with body mass index (BMI) more than 25 kg/m.

CONCLUSIONS

These findings indicate MPV might play roles in inflammation in OLP. The red-form OLP might be associated with damage or reduction of kidney function.

摘要

背景

本回顾性观察研究旨在评估中国口腔扁平苔藓（OLP）患者的血小板计数、平均血小板体积（MPV）和肝肾功能血液生化指标。

方法

纳入 80 例经病理证实的 OLP 患者和 51 名健康对照者。从医院电子病历系统获取全血细胞计数和生化检测数据。

结果

与对照组相比，OLP 患者的 MPV 升高（10.68±0.97 fL 比 10.33±0.89 fL，P=0.042），而血小板计数无差异。红型 OLP 组的血尿素氮（BUN）高于白型 OLP 组（5.24±1.15 mmol/L 比 4.69±0.98 mmol/L，P=0.036）。相比之下，两组间其他变量，包括 MPV、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和肌酐，均无差异。92.5%的 OLP 患者的 C 反应蛋白（CRP）值低于 3.48 mg/L。此外，75%的 OLP 患者超重，体重指数（BMI）大于 25 kg/m²。