Mitiku Asaye, Aklilu Addis, Biresaw Gelila, Gize Addisu
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.
Infect Drug Resist. 2021 Jun 9;14:2133-2142. doi: 10.2147/IDR.S306648. eCollection 2021.
Urinary tract infection (UTI) is a very frequent infection both in the community and hospital patients, and the emergence of methicillin-resistant (MRSA) in the community setting and infections with this pathogen become a prevalent problem among UTI patients. Therefore, the aim of this study was to determine prevalence and associated factors of methicillin resistance (MRSA) among urinary tract infection suspected patients attending at Arba Minch General Hospital.
Facility-based cross-sectional study was done at Arba Minch General Hospital from July to October 2020. Midstream urine specimen was collected from outpatients, cultured and biochemical tests were performed to identify the intended pathogen, finally the antibiotic susceptibility pattern of MRSA was done and possible associated factors were determined. The cleaned data were entered and analyzed using SPSS version 21.
Four hundred and twenty two (422) adult outpatients were enrolled in this study, of which males accounted for 238 (56.4%) of the participants. The mean and standard deviation age of the participants was 27.4 (SD 27.4 ± 15.6) years. A total of 54 isolates were recovered from urine specimen. The prevalence of MRSA among the isolated was 23/54 (42.59% (95% CI (35.0, 47.0)). Participants who had previous exposure to UTI (p < 0.002), presence of chronic disease (p < 0.029), and hospitalization (p < 0.006) were statically associated with the prevalence of MRSA. From all the MRSA isolates, 53.7% were resistant against Nitrofurantoin.
This study revealed that MRSA could be prevalent in isolates from patients suspected of urinary tract infection and exhibiting different resistance pattern for antibiotics commonly used for treatment of staphylococcal infections.
尿路感染（UTI）在社区和医院患者中都是非常常见的感染，社区环境中耐甲氧西林金黄色葡萄球菌（MRSA）的出现以及该病原体引起的感染在UTI患者中成为一个普遍问题。因此，本研究的目的是确定阿尔巴明奇综合医院疑似尿路感染患者中耐甲氧西林（MRSA）的患病率及相关因素。
2020年7月至10月在阿尔巴明奇综合医院进行了基于机构的横断面研究。从门诊患者中收集中段尿标本，进行培养和生化试验以鉴定目标病原体，最后检测MRSA的抗生素敏感性模式并确定可能的相关因素。使用SPSS 21版输入并分析清理后的数据。
本研究纳入了422名成年门诊患者，其中男性占参与者的238名（56.4%）。参与者的平均年龄和标准差为27.4（标准差27.4±15.6）岁。共从尿标本中分离出54株菌株。分离株中MRSA的患病率为23/54（42.59%（95%可信区间（35.0，47.0））。既往有UTI暴露史（p<0.002）、患有慢性病（p<0.029）和住院（p<0.006）的参与者与MRSA的患病率在统计学上相关。在所有MRSA分离株中，53.7%对呋喃妥因耐药。
本研究表明，MRSA可能在疑似尿路感染患者的分离株中普遍存在，并且对常用于治疗葡萄球菌感染的抗生素表现出不同的耐药模式。
