Bhargava Vinant, Singh Kulwant, Meena Priti, Sanyal Rupan
Department of Nephrology, Institute of Renal Science, SIR Ganga Ram Hospital, New Delhi 110060, India.
Department of Nephrology, Ivy Hospital, Mohali Punjab 160071, India.
World J Nephrol. 2021 May 25;10(3):29-36. doi: 10.5527/wjn.v10.i3.29.
Gadolinium-based contrast agents (GBCAs) used in magnetic resonance imaging are vital in providing enhanced quality images, essential for diagnosis and treatment. Nephrogenic systemic fibrosis (NSF) with GBCAs has been a deterrent for the physician and has led to avoidance of these agents in patients with impaired kidney function. NSF is a progressive debilitating multisystem condition described classically in patients with renal insufficiency exposed to gadolinium contrast media. It is characterized by an induration and hardening of the skin. NSF is described to first involve the extremities and can imperceptibly involve internal organs. Lack of therapeutic interventions to treat NSF makes it more challenging and warrants deep insight into the pathogenesis, risk factors and treatment strategies.
磁共振成像中使用的钆基造影剂（GBCAs）对于提供高质量图像至关重要，而高质量图像对于诊断和治疗必不可少。钆基造影剂引发的肾源性系统性纤维化（NSF）一直是医生的一大顾虑，导致肾功能受损患者避免使用这些造影剂。NSF是一种进行性衰弱的多系统疾病，经典描述见于肾功能不全且接触钆造影剂的患者。其特征为皮肤硬结和硬化。NSF据描述首先累及四肢，且可不知不觉地累及内脏器官。由于缺乏治疗NSF的干预措施，使得该病更具挑战性，因此有必要深入了解其发病机制、危险因素和治疗策略。
