Ryoo Seung-Hwa, Kwon Dohyun, Lee Jong-Ho, Seo Kwang-Suk, Kim Hyun Jeong, Karm Myong-Hwan
Department of Dental Anesthesiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
J Dent Anesth Pain Med. 2021 Jun;21(3):261-268. doi: 10.17245/jdapm.2021.21.3.261. Epub 2021 Jun 1.
Hemophilia A is a hemorrhagic disease caused by coagulation factor VIII deficiency. In head and neck cancer surgery, especially during a reconstructive one, complications can occur. These include hematomas due to bleeding which can then lead to flap ischemia, necrosis, and impaired wound healing. There are fewer cases of reconstructive surgery in patients with hemophilia A. Here in we report, a reconstructive surgery that involved mass resection, partial glossectomy (right), selective neck dissection (right, Levels I, II, III, IV), and reconstruction at the lateral arm free flap (left) in a 25-year-old man with hemophilia A. The surgery was successfully performed without any complications after pretreatment with Factor VIII concentrate, which has not been reported earlier.
甲型血友病是一种由凝血因子 VIII 缺乏引起的出血性疾病。在头颈癌手术中，尤其是重建手术期间，可能会出现并发症。这些并发症包括出血导致的血肿，进而可能导致皮瓣缺血、坏死和伤口愈合受损。甲型血友病患者进行重建手术的病例较少。在此我们报告一例针对一名 25 岁甲型血友病男性患者的重建手术，该手术包括肿物切除、部分舌切除术（右侧）、选择性颈部淋巴结清扫术（右侧，I、II、III、IV 区）以及左侧上臂游离皮瓣重建。在使用 VIII 因子浓缩物进行预处理后，手术成功完成，未出现任何并发症，此前未见相关报道。
