Kalicharan D, Jongebloed W L, van der Veen G, Los L I, Worst J G
Laboratory for Histology and Cell Biology, University of Groningen, The Netherlands.
Doc Ophthalmol. 1991;78(3-4):307-15. doi: 10.1007/BF00165694.
A male patients (42 years) who had been treated for retinal detachment by the implantation of a silicone plombe into the sclera, returned to the clinic 8 years after implantation because of inflammation of the tissue and partial protrusion from the sclera. After removal of the plombe this was processed for TEM and SEM and examination of the plombe material after 8 years in situ could be carried out in order to get information about the cell-biomaterial interface. A large proportion of the silicone pores was filled with cellular material, including macrophages, giant cells and erythrocytes thus indicating a foreign body granuloma. The external surface of the pores showed a granular osmiophilic dense amorphous layer including extracellular debris. Engulfing of silicone particles by macrophages and the evidence of long-term tissue response suggest partial biodegradation of the silicone and certainly not complete inertness as was formerly claimed.
一名42岁男性患者曾通过向巩膜植入硅酮压重块治疗视网膜脱离，植入8年后因组织炎症和部分从巩膜突出返回诊所。取出压重块后，将其进行透射电子显微镜（TEM）和扫描电子显微镜（SEM）处理，并对在位8年的压重块材料进行检查，以获取有关细胞 - 生物材料界面的信息。硅酮孔隙的很大一部分充满了细胞物质，包括巨噬细胞、巨细胞和红细胞，因此表明存在异物肉芽肿。孔隙的外表面显示出一层颗粒状嗜锇致密无定形层，包括细胞外碎片。巨噬细胞对硅酮颗粒的吞噬以及长期组织反应的证据表明硅酮存在部分生物降解，当然并非如以前所声称的那样完全惰性。
