Gustave Roussy, Université Paris-Saclay, France.
Bordeaux Population Health Research Center (BPH- INSERM U1219), Methods for Intervention Research in Population Health (MéRISP), Bordeaux University, France.
J Telemed Telecare. 2023 Oct;29(9):716-724. doi: 10.1177/1357633X211021743. Epub 2021 Jun 17.
Fatigue is one of the most frequent symptoms in anti-cancer immune therapy. Physical activity has been proven effective in reducing fatigue, but unmet needs remain regarding the provision and access to adapted programmes, which efficiently addresses the main barriers to PA.
The PACTIMe-FEAS study primarily aimed at primarily to evaluate the feasibility and the acceptability of a videoconference-based 6-month programme promoting physical activity, and secondarily to assess its potential post-immediate and short-term effectiveness in reducing fatigue in cancer patients under immune therapy. Numeric self-reported questionnaires (Visual Analogue Scale-fatigue, Multidimensional Fatigue Inventory, International Physical Activity Questionnaire, Échelle de Motivation envers l'Activité Physique en contexte de Santé, Medical Outcomes Study 36-Item Short Form Health Survey, Hospital Anxiety and Depression Scale and Insomnia Severity Index) were completed by participants through an online secure platform at three time points: just before (T1), and after (T2) the programme, and 3 months later (T3).
Sixteen participants (50% male, 50% female, mean age 54 years, 69% melanoma, 31% overweight), with moderate-to-severe fatigue, entered the internet-delivered intervention; 14 completed it, with an average completion rate of physical activity supervised sessions of 75%. Satisfaction was high, confirming a demand for group format, personalised approach, professional guidance and home-based device, to support the practice of regular physical activity. A decrease in fatigue was observed at the end of the programme.
The recruitment process did prove to be challenging, with a relatively small eligible population, and will need to be reconsidered to envision a larger scale trial. But here and now, this feasibility study provides the first promising foundations to develop further research on the effectiveness of an original remote programme.
疲劳是癌症免疫治疗中最常见的症状之一。身体活动已被证明可以有效减轻疲劳，但在提供和获得适应计划方面仍存在未满足的需求，这些计划可以有效地解决身体活动的主要障碍。
PACTIMe-FEAS 研究主要旨在评估基于视频会议的 6 个月促进身体活动的方案的可行性和可接受性，其次评估其在免疫治疗下的癌症患者中立即和短期减少疲劳的潜在效果。参与者通过在线安全平台完成了数字自我报告问卷（疲劳视觉模拟量表、多维疲劳量表、国际身体活动问卷、健康背景下的身体活动动机量表、医疗结果研究 36 项简短健康调查问卷、医院焦虑和抑郁量表和失眠严重程度指数），在三个时间点完成：在方案开始前（T1）、结束后（T2）和 3 个月后（T3）。
16 名参与者（50%男性，50%女性，平均年龄 54 岁，69%黑素瘤，31%超重），患有中度至重度疲劳，参加了互联网提供的干预措施；14 名参与者完成了干预，平均完成率为 75%监督的身体活动课程。满意度很高，证实了对小组形式、个性化方法、专业指导和家庭设备的需求，以支持定期身体活动的实践。在方案结束时观察到疲劳减轻。
招募过程确实具有挑战性，合格的人口相对较少，需要重新考虑，以设想更大规模的试验。但在这里和现在，这项可行性研究为进一步研究原始远程方案的有效性提供了第一个有希望的基础。
