Alpua Murat, Say Bahar, Yardimci Ilknur, Ergün Ufuk, Kisa Ucler, Ceylan Ozlem Doğan
Department of Neurology, Kirikkale University, Faculty of Medicine, Kirikkale, Turkey.
Department of Biochemistry, Kirikkale University, Faculty of Medicine, Kirikkale, Turkey.
Rambam Maimonides Med J. 2021 Jul 20;12(3):e0021. doi: 10.5041/RMMJ.10440.
Our study aimed to determine the relationship between serum periostin levels, and the neutrophil-lymphocyte ratio (NLR) with ischemic stroke subtypes, clinical stroke scales, and acute prognosis in patients with acute ischemic stroke.
Forty-two ischemic stroke patients and 39 age- and sex-matched healthy volunteers were included in our study. Demographic characteristics including age and gender were recorded. Blood serum periostin and NLR values were evaluated in the first 24 hours after admission. Serum periostin levels were compared with healthy controls of similar age and sex. Lesion localization was determined by cranial CT or diffusion MRI of the patients. Stroke scales were recorded on days 1 and 7 of hospitalization in the study group.
The mean serum periostin levels were higher than in the control group, but no statistically significant difference was found. There was no correlation between serum periostin levels and prognosis of stroke. First admission NLRs were statistically higher than in the control group. The first admission NLRs were positively correlated with the first admission National Institute of Health Stroke Scale score and the day 7 modified Rankin score.
Our study is the first study to evaluate both NLR and serum periostin levels in all types of acute ischemic stroke. While our study did not show that first admission serum periostin levels can be used as a biomarker in ischemic stroke, it did indicate that the first admission NLR can be used for acute prognosis of ischemic stroke.
本研究旨在确定急性缺血性脑卒中患者血清骨膜蛋白水平、中性粒细胞与淋巴细胞比值（NLR）与缺血性卒中亚型、临床卒中量表及急性预后之间的关系。
本研究纳入了42例缺血性脑卒中患者以及39例年龄和性别匹配的健康志愿者。记录包括年龄和性别的人口统计学特征。在入院后的头24小时内评估血清骨膜蛋白和NLR值。将血清骨膜蛋白水平与年龄和性别相似的健康对照进行比较。通过患者的头颅CT或弥散MRI确定病变定位。在研究组住院的第1天和第7天记录卒中量表。
血清骨膜蛋白平均水平高于对照组，但未发现统计学上的显著差异。血清骨膜蛋白水平与卒中预后之间无相关性。首次入院时的NLR在统计学上高于对照组。首次入院时的NLR与首次入院时的美国国立卫生研究院卒中量表评分以及第7天的改良Rankin量表评分呈正相关。
本研究是首个评估所有类型急性缺血性脑卒中患者NLR和血清骨膜蛋白水平的研究。虽然本研究未表明首次入院时的血清骨膜蛋白水平可作为缺血性脑卒中的生物标志物，但确实表明首次入院时的NLR可用于缺血性脑卒中的急性预后评估。
