Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Curr Med Chem. 2021;28(25):5034-5047. doi: 10.2174/0929867328666210617105209.
The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.
干扰素诱导的四肽重复蛋白（IFIT）家族是抗病毒免疫反应的重要组成部分。目前已知人类有四种 IFIT 家族成员，即 IFIT1、IFIT2、IFIT3 和 IFIT5。最近的发现引起了人们对 IFIT 在癌症中的重要作用的关注。本综述总结了不同 IFIT 蛋白在各种恶性肿瘤中的生物学作用的最新知识，并强调了这些分子作为癌症生物标志物和预后因素的潜在用途。
