Jansen H M, The T H, de Gast G C, Huiges H A, Esselink M T, van der Wal A M, Orie N G
Thorax. 1977 Dec;32(6):706-10. doi: 10.1136/thx.32.6.706.
, , 706-710. Inclusions in peripheral blood polymorphonuclear leucocytes (PMN) of 23 patients with bronchial carcinoma, of 11 individuals with chronic obstructive lung disease (COLD), and of 11 healthy controls were studied by the indirect immunofluorescence technique for IgG and complement. The relationships of these inclusions to the clinical stage and histology of the malignant disease as well as the influence of subsequent therapy were studied. Patients with disseminated bronchial carcinoma, stage III, had higher PMN scores than patients with localised disease, stage I. Both patient groups had higher scores than the two control groups. The differences were all statistically significant. There was no difference between the COLD group and the healthy controls. PMN inclusion scores from the patient group with small- or large-cell undifferentiated carcinoma were higher than from patients with moderately differentiated or well differentiated squamous-cell carcinoma. The first two groups differed significantly from the controls; the latter group did not. Curative surgical therapy gave rise to a significant drop in PMN scores to normal values. In four patients with regional lymph node metastasis (stage II) the PMN inclusions were related to evidence of recurrence at six months follow-up after operation and BCG immunostimulation. It is concluded that the PMN inclusions are related to the extent of the disease, to the histological type, and to curative surgical therapy. The possible relation to immune complexes of tumour antigen-antibody origin is discussed.
对23例支气管癌患者、11例慢性阻塞性肺疾病（COLD）患者及11名健康对照者外周血多形核白细胞（PMN）中的包涵体进行了研究，采用间接免疫荧光技术检测IgG和补体。研究了这些包涵体与恶性疾病临床分期、组织学的关系以及后续治疗的影响。III期播散性支气管癌患者的PMN评分高于I期局限性疾病患者。两组患者的评分均高于两个对照组。差异均具有统计学意义。COLD组与健康对照组之间无差异。小细胞或大细胞未分化癌患者组的PMN包涵体评分高于中分化或高分化鳞状细胞癌患者。前两组与对照组差异显著；后一组则无差异。根治性手术治疗使PMN评分显著下降至正常值。在4例有区域淋巴结转移（II期）的患者中，PMN包涵体与术后6个月随访及卡介苗免疫刺激时的复发证据有关。结论是PMN包涵体与疾病范围、组织学类型及根治性手术治疗有关。并讨论了其与肿瘤抗原 - 抗体来源免疫复合物的可能关系。
