• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.

作者信息

Garshick Michael S, Rosenthal Pamela B, Luttrell-Williams Elliot, Cronstein Bruce N, Berger Jeffrey S

机构信息

Center for the Prevention of Cardiovascular Disease, Department of Medicine.

Leon H. Charney Division of Cardiology, Department of Medicine.

出版信息

Rheumatology (Oxford). 2021 Nov 3;60(11):5473-5475. doi: 10.1093/rheumatology/keab481.

DOI:10.1093/rheumatology/keab481
PMID:34142122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8783537/
Abstract
摘要

相似文献

1
Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.替格瑞洛联合甲氨蝶呤可改善类风湿性关节炎的疾病严重程度。
Rheumatology (Oxford). 2021 Nov 3;60(11):5473-5475. doi: 10.1093/rheumatology/keab481.
2
Long-term followup of patients receiving combined therapy with cyclosporine and methotrexate.
Arthritis Rheum. 1998 Sep;41(9):1703-4. doi: 10.1002/1529-0131(199809)41:9<1703::AID-ART25>3.0.CO;2-D.
3
Use of methotrexate in the management of rheumatoid arthritis in Dakar. Potential pitfalls.
Rev Rhum Engl Ed. 1998 Dec;65(12):799-800.
4
[Therapy of rheumatoid arthritis with etanercept].用依那西普治疗类风湿关节炎
Internist (Berl). 2009 May;50(5):633-4. doi: 10.1007/s00108-009-2378-y.
5
A proposed treatment algorithm for rheumatoid arthritis: aggressive therapy, methotrexate, and quantitative measures.一种针对类风湿关节炎的治疗算法建议：强化治疗、甲氨蝶呤及定量措施。
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S209-10.
6
Therapies for active rheumatoid arthritis after methotrexate failure.甲氨蝶呤治疗失败后的活动性类风湿关节炎治疗方法。
N Engl J Med. 2013 Jul 25;369(4):307-18. doi: 10.1056/NEJMoa1303006. Epub 2013 Jun 11.
7
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.利妥昔单抗联合甲氨蝶呤治疗早期活动性类风湿关节炎的疗效：IMAGE 试验。
Ann Rheum Dis. 2011 Jan;70(1):39-46. doi: 10.1136/ard.2010.137703. Epub 2010 Oct 11.
8
Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial.托珠单抗、甲氨蝶呤或二者联合治疗早期类风湿关节炎（U-Act-Early）：一项多中心、随机、双盲、双模拟、策略试验。
Lancet. 2016 Jul 23;388(10042):343-355. doi: 10.1016/S0140-6736(16)30363-4. Epub 2016 Jun 7.
9
Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.阿达木单抗联合甲氨蝶呤和关节内曲安奈德治疗早期类风湿关节炎的靶向治疗策略可提高缓解率、功能和生活质量。OPERA 研究：一项由研究者发起的、随机、双盲、平行分组、安慰剂对照试验。
Ann Rheum Dis. 2014 Apr;73(4):654-61. doi: 10.1136/annrheumdis-2012-202735. Epub 2013 Feb 23.
10
Is methotrexate plus cyclosporine A a useful salvage therapy for rheumatoid arthritis patients unresponsive to other types of methotrexate combination treatment?
Clin Exp Rheumatol. 2002 Sep-Oct;20(5):737.

引用本文的文献

1
Platelets as drivers of immunothrombosis in rheumatic diseases.血小板作为风湿性疾病中免疫血栓形成的驱动因素。
Nat Rev Rheumatol. 2025 Jul 7. doi: 10.1038/s41584-025-01276-z.
2
The Signaling Pathway of the ADP Receptor P2Y in the Immune System: Recent Discoveries and New Challenges.免疫系统中 ADP 受体 P2Y 的信号通路：最新发现与新挑战。
Int J Mol Sci. 2023 Apr 4;24(7):6709. doi: 10.3390/ijms24076709.

本文引用的文献

1
Methotrexate and its mechanisms of action in inflammatory arthritis.甲氨蝶呤及其在炎症性关节炎中的作用机制。
Nat Rev Rheumatol. 2020 Mar;16(3):145-154. doi: 10.1038/s41584-020-0373-9. Epub 2020 Feb 17.
2
Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression.内源性腺苷维持软骨稳态，外源性腺苷抑制骨关节炎进展。
Nat Commun. 2017 May 11;8:15019. doi: 10.1038/ncomms15019.
3
Activated Platelets Induce Endothelial Cell Activation via an Interleukin-1β Pathway in Systemic Lupus Erythematosus.活化血小板通过白细胞介素-1β途径诱导系统性红斑狼疮患者的内皮细胞活化。
Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):707-716. doi: 10.1161/ATVBAHA.116.308126. Epub 2017 Feb 2.
4
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.2015 年美国风湿病学会类风湿关节炎治疗指南。
Arthritis Rheumatol. 2016 Jan;68(1):1-26. doi: 10.1002/art.39480. Epub 2015 Nov 6.
5
Disease activity in rheumatoid arthritis and the risk of cardiovascular events.类风湿关节炎的疾病活动度与心血管事件风险。
Arthritis Rheumatol. 2015 Jun;67(6):1449-55. doi: 10.1002/art.39098.
6
Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevance.替格瑞洛介导的腺苷作用：证据与潜在临床意义。
J Am Coll Cardiol. 2014 Jun 17;63(23):2503-2509. doi: 10.1016/j.jacc.2014.03.031. Epub 2014 Apr 23.
7
Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate-resistant mice do not.甲氨蝶呤敏感型小鼠的成纤维细胞积累甲氨蝶呤多聚谷氨酸，但甲氨蝶呤耐药型小鼠的成纤维细胞则不会。
Clin Exp Rheumatol. 2013 May-Jun;31(3):433-5. Epub 2013 Mar 4.