Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Graefes Arch Clin Exp Ophthalmol. 2021 Nov;259(11):3295-3303. doi: 10.1007/s00417-021-05270-5. Epub 2021 Jun 18.
To report the long-term changes of the size of myopic choroidal neovascularization (mCNV) using optical coherence tomography angiography (OCTA).
This was a retrospective, observational case study of eleven eyes in eleven patients with mCNV followed with OCTA for a minimum of 3 years. The flow area of mCNV on OCTA, the size of chorioretinal atrophy (CRA) and central choroidal thickness were analyzed. The relationship between the changes of mCNV size and recurrences treated with anti-vascular endothelial growth factor (VEGF) agents was also assessed.
Three eyes out of eleven eyes showed enlargement of the mCNV over 3 years. In two of the three eyes, the mCNV recurrences had not been treated immediately (the examination intervals were 4 months and 5 months, respectively), and we found obvious enlargement of the mCNV. In three eyes, the mCNV size decreased in 1 year and was stable thereafter without recurrences. In five eyes, mCNV size did not show remarkable changes for 3 years. In three of the five eyes, no recurrences were detected and two of the five eyes underwent prompt treatments against recurrences.
Regular examination and prompt treatments against recurrences are critical to prevent enlargement of mCNV.
利用光相干断层扫描血管造影术（OCTA）报告近视性脉络膜新生血管（mCNV）大小的长期变化。
这是一项回顾性、观察性病例研究，纳入了 11 名患者的 11 只眼，这些患者均患有 mCNV，并接受了至少 3 年的 OCTA 随访。分析 mCNV 在 OCTA 上的血流面积、脉络膜视网膜萎缩（CRA）大小和中心脉络膜厚度。还评估了 mCNV 大小变化与抗血管内皮生长因子（VEGF）药物治疗后复发之间的关系。
11 只眼中有 3 只眼在 3 年内 mCNV 增大。在这 3 只眼中的 2 只眼中，mCNV 复发未立即治疗（检查间隔分别为 4 个月和 5 个月），我们发现 mCNV 明显增大。在 3 只眼中，mCNV 大小在 1 年内减小，此后保持稳定且无复发。在 5 只眼中，mCNV 大小在 3 年内无明显变化。在这 5 只眼中，有 3 只眼未发现复发，有 2 只眼对复发进行了及时治疗。
定期检查和及时治疗复发对于防止 mCNV 增大至关重要。
