Liu Jing, Song Shuang, Yu Xiaobing
Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China ; and.
Graduate School of Peking Union Medical College, Beijing, China .
Retina. 2022 Sep 1;42(9):1665-1672. doi: 10.1097/IAE.0000000000003526.
To identify baseline morphological predictors of lesion shrinkage in eyes with myopic choroidal neovascularization (mCNV) treated with anti-vascular endothelial growth factor.
This retrospective study included 46 eyes (41 consecutive patients) with active mCNV receiving anti-vascular endothelial growth factor treatment. Optical coherence tomography angiography was performed at baseline and 1 year after treatment. Quantitative features were obtained from optical coherence tomography angiography images using AngioTool software. Eyes were classified as "high shrinkage" or "low shrinkage" according to the median relative change in lesion area. Baseline quantitative morphological features associated with mCNV shrinkage were identified in univariate and multivariate analyses.
The mCNV area was significantly smaller after 1 year ( P = 0.013), with a median relative change of -16.5%. The relative change in mCNV area was -48.3% in high-shrinkage eyes (n = 23) and -5.2% in low-shrinkage eyes (n = 23). High-shrinkage eyes had a smaller mCNV area ( P = 0.013), shorter total vessel length ( P = 0.023), and higher end point density ( P < 0.001). Multivariate analysis showed significant associations of high shrinkage with end point density (β = -0.037, P = 0.043) and previous anti-vascular endothelial growth factor treatment (β = 0.216, P = 0.029).
Morphological features of neovascularization detected by optical coherence tomography angiography can predict lesion shrinkage in eyes with mCNV receiving anti-vascular endothelial growth factor therapy. Higher end point density contributed to shrinkage, particularly of treatment-naive lesions.
确定接受抗血管内皮生长因子治疗的近视性脉络膜新生血管（mCNV）眼病变缩小的基线形态学预测指标。
这项回顾性研究纳入了46只眼（41例连续患者）活动性mCNV接受抗血管内皮生长因子治疗。在基线和治疗后1年进行光学相干断层扫描血管造影。使用AngioTool软件从光学相干断层扫描血管造影图像中获取定量特征。根据病变面积的中位数相对变化将眼部分为“高缩小”或“低缩小”。在单变量和多变量分析中确定与mCNV缩小相关的基线定量形态学特征。
1年后mCNV面积显著减小（P = 0.013），中位数相对变化为-16.5%。高缩小眼（n = 23）的mCNV面积相对变化为-48.3%，低缩小眼（n = 23）为-5.2%。高缩小眼的mCNV面积较小（P = 0.013），总血管长度较短（P = 0.023），终点密度较高（P < 0.001）。多变量分析显示高缩小与终点密度（β = -0.037，P = 0.043）和既往抗血管内皮生长因子治疗（β = 0.216，P = 0.029）显著相关。
光学相干断层扫描血管造影检测到的新生血管形态学特征可预测接受抗血管内皮生长因子治疗的mCNV眼病变缩小。较高的终点密度有助于病变缩小，尤其是未接受过治疗的病变。
