Keren G, Katz S, Strom J, Sonnenblick E H, LeJemtel T H
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Am Heart J. 1988 Sep;116(3):758-64. doi: 10.1016/0002-8703(88)90334-1.
The presence and severity of functional mitral regurgitation were quantified by Doppler echocardiography in 17 patients with dilated cardiomyopathy and no evidence of primary valvular disease. Mitral regurgitant fraction was greater than 20% in 11 of the 17 patients, and exceeded 40% in four patients. Total stroke volume, calculated from the difference between end-diastolic and end-systolic volumes obtained by two-dimensional echocardiography, correlated well with mitral valve inflow determined by Doppler echocardiography (r = 0.90, p less than 0.001). Similarly, mitral regurgitant volume, calculated as the difference between echocardiographic total stroke volume and forward aortic volume obtained by Doppler echocardiography, correlated well with regurgitant volume calculated as the difference between mitral valve inflow and forward aortic flow, both determined by Doppler echocardiography (r = 0.90, p less than 0.001). Accordingly, functional mitral regurgitation can be conveniently demonstrated in patients with dilated cardiomyopathy by two different Doppler echocardiography methods, whose results are closely correlated. Mitral regurgitant fraction is greater than 20% in two thirds of the patients with a dilated cardiomyopathy.
采用多普勒超声心动图对17例扩张型心肌病且无原发性瓣膜病证据的患者进行功能性二尖瓣反流的存在情况及严重程度的量化评估。17例患者中有11例二尖瓣反流分数大于20%，4例超过40%。通过二维超声心动图获得的舒张末期和收缩末期容积之差计算得出的总心搏量，与多普勒超声心动图测定的二尖瓣瓣口血流密切相关（r = 0.90，p < 0.001）。同样，通过超声心动图总心搏量与多普勒超声心动图获得的主动脉前向血流容积之差计算得出的二尖瓣反流容积，与通过多普勒超声心动图测定的二尖瓣瓣口血流与主动脉前向血流之差计算得出的反流容积密切相关（r = 0.90，p < 0.001）。因此，通过两种不同的多普勒超声心动图方法可以方便地在扩张型心肌病患者中显示功能性二尖瓣反流，且两种方法的结果密切相关。三分之二的扩张型心肌病患者二尖瓣反流分数大于20%。
