Zhang Y, Ihlen H, Myhre E, Levorstad K, Nitter-Hauge S
Medical Department B, Rikshospitalet, Oslo, Norway.
Eur Heart J. 1987 Aug;8 Suppl C:59-62. doi: 10.1093/eurheartj/8.suppl_c.59.
The present study was undertaken to evaluate a new non-invasive approach to the quantification of mitral regurgitation. Doppler echocardiography and left ventriculography were performed in 20 patients without valvular heart disease (group A), and in 30 patients with pure mitral regurgitation (group B). Volumetric flows through the aortic and mitral valve orifices were determined by Doppler technique. The aortic flow (AF) was calculated as the product of the aortic orifice area by the systolic velocity integral. The mitral flow (MF) was computed as the product of the corrected mitral orifice area by the diastolic velocity integral. The mitral regurgitant fraction (RF) was calculated as: RF = 1 - AF/MF. In group A, there was a close agreement between aortic and mitral flows (r = 0.94, P less than 0.001), and there was no significant difference between the two measurements. In group B, the mitral flow was significantly higher than the aortic flow. The regurgitant fraction assessed by Doppler echocardiography correlated well with the grades of severity of regurgitation obtained at left ventriculography. We conclude that combined measurement of both aortic and mitral flows by Doppler echocardiography provides a new and promising approach to the noninvasive quantification of mitral regurgitation.
本研究旨在评估一种用于二尖瓣反流定量分析的新的非侵入性方法。对20例无瓣膜性心脏病患者（A组）和30例单纯二尖瓣反流患者（B组）进行了多普勒超声心动图和左心室造影检查。通过多普勒技术测定通过主动脉瓣和二尖瓣口的容积流量。主动脉流量（AF）计算为主动脉口面积与收缩期速度积分的乘积。二尖瓣流量（MF）计算为校正后的二尖瓣口面积与舒张期速度积分的乘积。二尖瓣反流分数（RF）计算如下：RF = 1 - AF/MF。在A组中，主动脉流量与二尖瓣流量密切相关（r = 0.94，P < 0.001），且两种测量之间无显著差异。在B组中，二尖瓣流量显著高于主动脉流量。多普勒超声心动图评估的反流分数与左心室造影获得的反流严重程度分级密切相关。我们得出结论，通过多普勒超声心动图联合测量主动脉和二尖瓣流量为二尖瓣反流的非侵入性定量分析提供了一种新的、有前景的方法。
