Chimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris, UMR8247, Paris, 75005, France.
Macromol Rapid Commun. 2021 Aug;42(15):e2100194. doi: 10.1002/marc.202100194. Epub 2021 Jun 18.
Polymer cubosomes and hexosomes are polymer colloids with inverted lyotropic liquid crystal phases as internal structures. They are composed of regular networks of water-filled channels surrounded by a bilayer membrane made from amphiphilic block copolymers. Due to the uniform, tunable, and highly ordered porous structure, polymer cubosomes and hexosomes present numerous advantages over polymer micelles and vesicles, such as the high loading volumes for both hydrophilic and hydrophobic substances, large specific surface areas, and good mechanical and chemical stabilities. The polymer chemistry also enables unlimited molecular design to endow these polymer colloids with a lot of adjustable physical and chemical properties. Therefore, polymer cubosomes and hexosomes have attracted increasing attention for their potential applications in materials science and nanotechnology. This review outlines the recent progress in this field with an emphasis on the polymer architectures, the self-assembly conditions and mechanisms, and some application examples which are special for these inverted polymer colloids. It is hoped to provide some practical guidance for researchers interested in polymer cubosomes and hexosomes.
聚合物立方胶束和六方胶束是具有反胶束液晶相的聚合物胶体，其内部结构为规则的水填充通道网络，由两亲嵌段共聚物组成的双层膜包围。由于具有均匀、可调且高度有序的多孔结构，聚合物立方胶束和六方胶束在亲水和疏水物质的高装载量、大比表面积以及良好的机械和化学稳定性方面，优于聚合物胶束和囊泡。聚合物化学还可以进行无限的分子设计，赋予这些聚合物胶体许多可调的物理和化学性质。因此，聚合物立方胶束和六方胶束因其在材料科学和纳米技术中的潜在应用而受到越来越多的关注。本文重点介绍了该领域的最新进展，包括聚合物结构、自组装条件和机制以及一些特殊的应用实例，希望为对聚合物立方胶束和六方胶束感兴趣的研究人员提供一些实用的指导。
