COVID-19 与乳糜泻：乳糜泻爆发的一种发病假说。
COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak.
机构信息
Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Hepatology Gastroenterology and Nutrition Unit, "Bambino Gesù" Children Hospital, Rome, Italy.
出版信息
Int J Clin Pract. 2021 Sep;75(9):e14452. doi: 10.1111/ijcp.14452. Epub 2021 Jun 17.
Abstract
BACKGROUND
A growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa: the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.
METHODS
Based on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.
CONCLUSIONS
Genetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.
摘要
背景
越来越多的证据支持 SARS-CoV-2 的肠道营养作用，由于 ACE2 和 TMPRSS2 的高表达，纤毛细胞和肠上皮细胞成为靶细胞。事实上，COVID-19 在肠道黏膜中引发“细胞因子风暴”：由此导致的上皮损伤导致屏障通透性增加，允许肠黏膜中的麦胶通过。
方法
根据目前的文献，我们假设 COVID-19 可能是易患患者中乳糜泻的潜在触发因素。
结论
遗传易患患者在感染 SARS-CoV-2 后更有可能患上乳糜泻，因此 COVID-19 可能是未来乳糜泻潜在爆发的罪魁祸首之一。
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