Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.
Hepatology Gastroenterology and Nutrition Unit, "Bambino Gesù" Children Hospital, Rome, Italy.
Int J Clin Pract. 2021 Sep;75(9):e14452. doi: 10.1111/ijcp.14452. Epub 2021 Jun 17.
A growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa: the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.
Based on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.
Genetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.
越来越多的证据支持 SARS-CoV-2 的肠道营养作用，由于 ACE2 和 TMPRSS2 的高表达，纤毛细胞和肠上皮细胞成为靶细胞。事实上，COVID-19 在肠道黏膜中引发“细胞因子风暴”：由此导致的上皮损伤导致屏障通透性增加，允许肠黏膜中的麦胶通过。
根据目前的文献，我们假设 COVID-19 可能是易患患者中乳糜泻的潜在触发因素。
遗传易患患者在感染 SARS-CoV-2 后更有可能患上乳糜泻，因此 COVID-19 可能是未来乳糜泻潜在爆发的罪魁祸首之一。
