基于 NHANES 和孟德尔随机化研究的脂肪酸摄入与乳腺癌的相关性。

The association between fatty acid intake and breast cancer based on the NHANES and Mendelian randomization study.

机构信息

Epidemiology and Biostatistics, School of Public Health, No. 1163 Xinmin Street, Jilin University, Changchun, Jilin, 130021, China.

Department of Child and Adolescent Health, School of Public Health, No. 1163 Xinmin Street, Jilin University, Changchun, Jilin, 130021, China.

出版信息

Cancer Epidemiol. 2021 Aug;73:101966. doi: 10.1016/j.canep.2021.101966. Epub 2021 Jun 17.

DOI:10.1016/j.canep.2021.101966

PMID:34146915

Abstract

BACKGROUND

Observational studies have examined the association between fatty acid intake and breast cancer (BC), and the association might vary depending on menopausal status, but the results remain controversial. The objective of this study was to investigate the associations between fatty acid intake and BC.

METHODS

The National Health and Nutrition Examination Survey (NHANES) 1999-2016 was used in the study, and stratified analysis by menopausal status was performed. Logistic regression models were used to evaluate the associations between BC and intake of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs), adjusting for covariates. Three two-sample Mendelian randomization (MR) methods-inverse variance weighted (IVW), weighted median, and Mendelian randomization-Egger (MR-Egger) regression-were applied to further verify the associations between intake of fatty acids and BC.

RESULTS

Higher intake of MUFAs was associated with lower risk of BC in premenopausal women: ORs (95 %CI): 0.325 (0.110, 0.964). IVW showed that increased intake of MUFAs was associated with a reduced risk of BC: 0.997 (0.995, 1.000), p = 0.024. No associations between BC and SFAs, MUFAs or PUFAs were found in postmenopausal women or in the overall population.

CONCLUSIONS

Increasing intake of MUFAs might reduce the risk of BC in premenopausal women. The protective effect of MUFAs on BC was also supported by MR study.

摘要

背景

观察性研究已经研究了脂肪酸摄入与乳腺癌（BC）之间的关联，并且这种关联可能因绝经状态而异，但结果仍存在争议。本研究的目的是探讨脂肪酸摄入与 BC 之间的关系。

方法

本研究使用了 1999-2016 年全国健康与营养调查（NHANES）的数据，并按绝经状态进行了分层分析。使用逻辑回归模型评估了饱和脂肪酸（SFAs）、单不饱和脂肪酸（MUFAs）和多不饱和脂肪酸（PUFAs）的摄入与 BC 之间的关系，并调整了协变量。应用三种双样本 Mendelian 随机化（MR）方法——逆方差加权（IVW）、加权中位数和 Mendelian 随机化-Egger（MR-Egger）回归——进一步验证了脂肪酸摄入与 BC 之间的关系。

结果

较高的 MUFA 摄入量与绝经前妇女 BC 的风险降低相关：比值比（95%置信区间）：0.325（0.110，0.964）。IVW 显示 MUFA 摄入量的增加与 BC 风险的降低相关：0.997（0.995，1.000），p=0.024。在绝经后妇女或总体人群中，SFAs、MUFAs 或 PUFAs 与 BC 之间均无关联。