Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Endocr Disord. 2021 Jun 19;21(1):125. doi: 10.1186/s12902-021-00789-4.
Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to be the leading cause of chronic liver disease worldwide. This study aims to systematically review and meta-analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver.
Following a systematic review and meta-analysis method, articles without any time limitation, were extracted from SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed and ScienceDirect international databases. Random effects model was used for analysis, and heterogeneity of studies was investigated considering the I index and using Comprehensive Meta-Analysis software.
The odds ratio of CC genotype in patients with non-alcoholic fatty liver demonstrates the protective effect of CC genotype with the ratio of 0.52, whereas CG genotype presents an increasing effect of CG genotype with the ratio of 0.19, and GG genotype also showed an increasing effect of GG genotype with the ratio of 1.05. Moreover, CG + GG genotypes as a single group demostrated an odds rartio of 0.88.
This meta-analysis highlights that people with CC genotype has 52% lower chance of developing non-alcoholic fatty liver disease, and those with CG genotype had 19% higher risk of developing non-alcoholic fatty liver. Those with GG genotype were 105% more likely to develop non-alcoholic fatty liver than others. Moreover, those present in a population with CG + GG genotypes were 88% more likely to have non-alcoholic fatty liver disease.
非酒精性脂肪性肝病（NAFLD）是一种常见疾病，已知是全球慢性肝病的主要原因。本研究旨在系统地回顾和荟萃分析 PNPLA3 rs738409 多态性与非酒精性脂肪性肝病的关系。
按照系统回顾和荟萃分析的方法，从 SID、MagIran、IranDoc、Scopus、Embase、Web of Science（WoS）、PubMed 和 ScienceDirect 国际数据库中提取无时间限制的文章。使用随机效应模型进行分析，并考虑 I 指数和使用 Comprehensive Meta-Analysis 软件来研究研究的异质性。
非酒精性脂肪肝患者 CC 基因型的优势比表明 CC 基因型具有保护作用，比值为 0.52，而 CG 基因型表现出 CG 基因型的增加作用，比值为 0.19，GG 基因型也表现出 GG 基因型的增加作用，比值为 1.05。此外，CG + GG 基因型作为一个单一的组，表现出 0.88 的优势比。
这项荟萃分析强调，CC 基因型的人患非酒精性脂肪性肝病的几率降低 52%，CG 基因型的人患非酒精性脂肪性肝病的风险增加 19%。GG 基因型的人患非酒精性脂肪性肝病的可能性比其他人高 105%。此外，CG + GG 基因型存在于人群中的人患非酒精性脂肪性肝病的可能性增加 88%。
