Garabedian-Ruffalo S M, Syrja-Farber M, Lanius P M, Plucinski A
George Washington University Medical Center (GWUMC), Washington, DC.
Am J Hosp Pharm. 1988 Jul;45(7):1530-4.
A program for detecting and preventing potentially serious drug-drug and drug-food interactions is described. Two clinical pharmacists developed drug interaction alert (DIA) cards for each potential interaction to be monitored. The cards contain information about the proposed mechanism and potential result of the interaction, as well as information about how to monitor or circumvent the interaction. Staff pharmacists check for the occurrence of potential interactions daily as they verify the filling of the patient-medication cassettes; a poster of all the interactions that are included in the program is posted in each satellite pharmacy to serve as a quick reference for the pharmacists. When a pharmacist detects a potential interaction, he or she completes a DIA card and places it in the medication cassette drawer (if the notice is directed to the nurse) or on the front of the patient's chart (if the notice is directed to the physician). The program was introduced to hospital personnel through inservice education programs and departmental newsletters. The results of a quality assurance review indicated that 95 of 279 (34%) cards dispensed to nurses and 40 of 49 (82%) cards dispensed to physicians resulted in some form of action. The program to detect and prevent potentially serious drug-drug and drug-food interactions has been successful.
本文描述了一个用于检测和预防潜在严重药物相互作用及药物与食物相互作用的程序。两名临床药剂师针对每种需要监测的潜在相互作用制作了药物相互作用警示（DIA）卡。卡片包含相互作用的推测机制和潜在结果的信息，以及关于如何监测或规避该相互作用的信息。药剂师在每日核查患者药盒装药情况时检查潜在相互作用的发生；该程序涵盖的所有相互作用的海报张贴在每个卫星药房，以便药剂师快速查阅。当药剂师检测到潜在相互作用时，他或她会填写一张DIA卡，并将其放在药盒抽屉中（如果通知是给护士的）或放在患者病历首页（如果通知是给医生的）。该程序通过在职教育项目和部门通讯介绍给医院工作人员。质量保证审查结果表明，分发给护士的279张卡片中有95张（34%），分发给医生的49张卡片中有40张（82%）引发了某种形式的行动。检测和预防潜在严重药物相互作用及药物与食物相互作用的程序取得了成功。
