Thomas J A, Burns R A
Department of Pharmacology, University of Texas Health Science Center, San Antonio, USA.
Drugs Aging. 1998 Sep;13(3):199-209. doi: 10.2165/00002512-199813030-00003.
Several drug-nutrient interactions can occur, but their prevalence may be accentuated in the elderly. Geriatric patients may experience age-related changes in the pharmacokinetics of a drug-absorption, distribution, metabolism and excretion. When drug-nutrient interactions occur, they usually affect absorptive processes more frequently. Specific transporter systems facilitate the absorption of many drugs. Little is known about how these transporter systems are affected by aging. Co-existing disease states in the elderly may exaggerate the action of a drug and represent a confounding factor in drug-nutrient interactions. While several different drug-nutrient interactions are important in the elderly, those affecting the cardiovascular system warrant special attention.
可能会发生多种药物与营养物质的相互作用，但在老年人中其发生率可能会更高。老年患者可能会经历与年龄相关的药物药代动力学变化，包括吸收、分布、代谢和排泄。当发生药物与营养物质的相互作用时，它们通常更频繁地影响吸收过程。特定的转运系统有助于许多药物的吸收。关于这些转运系统如何受到衰老影响，人们知之甚少。老年人并存的疾病状态可能会夸大药物的作用，并在药物与营养物质的相互作用中成为一个混杂因素。虽然几种不同的药物与营养物质的相互作用在老年人中都很重要，但那些影响心血管系统的相互作用值得特别关注。
